Recombinant Human LDB3 cell lysate

• Cat.No.: LDB3-977HCL

Specification

• Description: This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms (1 and 2) have C-terminal LIM domains.
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: LDB3 LIM domain binding 3 [ Homo sapiens ]
• Official Symbol: LDB3
• Synonyms: LDB3; LIM domain binding 3; LIM domain-binding protein 3; cypher; KIAA0613; oracle; PDLIM6; ZASP; protein cypher; PDZ and LIM domain 6; Z-band alternatively spliced PDZ-motif protein; CMD1C; LVNC3; CYPHER; LDB3Z1; LDB3Z4; ORACLE; FLJ35865; KIAA01613
• Gene ID: 11155
• mRNA Refseq: NM_001080114
• Protein Refseq: NP_001073583
• MIM: 605906
• UniProt ID: O75112
• Chromosome Location: 10q22.3-q23.2
• Function: cytoskeletal protein binding; metal ion binding; protein binding; zinc ion binding