Recombinant Human PCDHA4 cell lysate

• Cat.No.: PCDHA4-1296HCL

Specification

• Description: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: PCDHA4 protocadherin alpha 4 [ Homo sapiens (human) ]
• Official Symbol: PCDHA4
• Synonyms: PCDHA4; CNR1; CNRN1; CRNR1; PCDH-ALPHA4; protocadherin alpha 4; protocadherin alpha-4; PCDH-alpha-4; KIAA0345-like 10; ortholog of mouse CNR1
• Gene ID: 56144
• mRNA Refseq: NM_018907
• Protein Refseq: NP_061730
• MIM: 606310
• UniProt ID: Q9UN74
• Chromosome Location: 5q31
• Function: calcium ion binding