Recombinant Human PCDHGA11 cell lysate

• Cat.No.: PCDHGA11-1302HCL

Specification

• Description: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: PCDHGA11 protocadherin gamma subfamily A, 11 [ Homo sapiens ]
• Official Symbol: PCDHGA11
• Synonyms: PCDHGA11; protocadherin gamma subfamily A, 11; protocadherin gamma-A11; PCDH GAMMA A11; PCDH-GAMMA-A11
• Gene ID: 56105
• mRNA Refseq: NM_018914
• Protein Refseq: NP_061737
• MIM: 606298
• UniProt ID: Q9Y5H2
• Chromosome Location: 5q31
• Function: calcium ion binding