Recombinant Human PHOX2A cell lysate

• Cat.No.: PHOX2A-1347HCL

Specification

• Description: The protein encoded by this gene contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype. The encoded protein has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene. Mutations in this gene have been associated with autosomal recessive congenital fibrosis of the extraocular muscles.
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: PHOX2A paired-like homeobox 2a [ Homo sapiens ]
• Official Symbol: PHOX2A
• Synonyms: PHOX2A; paired-like homeobox 2a; aristaless (Drosophila) homeobox, aristaless homeobox (Drosophila), fibrosis of extraocular muscles, congenital, 2, autosomal recessive , ARIX, FEOM2, paired like (aristaless) homeobox 2a; paired mesoderm homeobox protein 2A; CFEOM2; PMX2A; arix homeodomain protein; ARIX1 homeodomain protein; aristaless homeobox homolog; aristaless homeobox protein homolog; ARIX; FEOM2; NCAM2; MGC52227
• Gene ID: 401
• mRNA Refseq: NM_005169
• Protein Refseq: NP_005160
• MIM: 602753
• UniProt ID: O14813
• Chromosome Location: 11q13.4
• Pathway: SIDS Susceptibility Pathways, organism-specific biosystem
• Function: RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity