"PKN1" Related Products

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Recombinant Human PKN1 cell lysate

Cat.No.: PKN1-1363HCL
Description: The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Species: Human
Size: 100 ul
Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Applications: Western Blot;
Gene Name: PKN1 protein kinase N1 [ Homo sapiens ]
Official Symbol: PKN1
Synonyms: PKN1; protein kinase N1; PRKCL1, protein kinase C like 1; serine/threonine-protein kinase N1; DBK; MGC46204; PAK1; PKN; PRK1; protein kinase C-like 1; protein kinase PKN-alpha; protein kinase C-like PKN; serine-threonine kinase N; protease-activated kinase 1; protein kinase C-related kinase 1; protein-kinase C-related kinase 1; serine-threonine protein kinase N; serine/threonine protein kinase N; PAK-1; PRKCL1; PKN-ALPHA;
Gene ID: 5585
mRNA Refseq: NM_002741
Protein Refseq: NP_002732
MIM: 601032
UniProt ID: Q16512
Chromosome Location: 19p13.12
Pathway: G13 Signaling Pathway, organism-specific biosystem; Regulation of Androgen receptor activity, organism-specific biosystem; RhoA signaling pathway, organism-specific biosystem; Salmonella infection, organism-specific biosystem; Salmonella infection, conserved biosystem; Signaling mediated by p38-gamma and p38-delta, organism-specific biosystem; TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem;
Function: ATP binding; GTP-Rho binding; Rac GTPase binding; androgen receptor binding; chromatin binding; histone binding; histone deacetylase binding; histone kinase activity (H3-T11 specific); ligand-dependent nuclear receptor transcription coactivator activity; ligand-dependent nuclear receptor transcription coactivator activity; nucleotide binding; protein binding; protein kinase C activity; protein kinase C binding; protein kinase activity; protein serine/threonine kinase activity;

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