Recombinant Human PRKAA2 cell lysate
Cat.No. : | PRKAA2-1413HCL |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. |
Species : | Human |
Size : | 100 ul |
Storage Buffer : | 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue) |
Applications : | Western Blot; |
Gene Name : | PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit [ Homo sapiens ] |
Official Symbol : | PRKAA2 |
Synonyms : | PRKAA2; protein kinase, AMP-activated, alpha 2 catalytic subunit; PRKAA; 5-AMP-activated protein kinase catalytic subunit alpha-2; AMPK; AMPKa2; AMPK-alpha-2 chain; AMPK subunit alpha-2; 5-AMP-activated protein kinase, catalytic alpha-2 chain; AMPK2; |
Gene ID : | 5563 |
mRNA Refseq : | NM_006252 |
Protein Refseq : | NP_006243 |
MIM : | 600497 |
UniProt ID : | P54646 |
Chromosome Location : | 1p31 |
Pathway : | AMPK inhibits chREBP transcriptional activation activity, organism-specific biosystem; AMPK signaling, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Energy Metabolism, organism-specific biosystem; Energy dependent regulation of mTOR by LKB1-AMPK, organism-specific biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; |
Function : | AMP-activated protein kinase activity; AMP-activated protein kinase activity; ATP binding; chromatin binding; histone serine kinase activity; metal ion binding; nucleotide binding; protein binding; protein binding, bridging; protein kinase activity; protein serine/threonine kinase activity; |
Products Types
◆ Recombinant Protein | ||
PRKAA2-7084M | Recombinant Mouse PRKAA2 Protein, His (Fc)-Avi-tagged | +Inquiry |
PRKAA2-4328R | Recombinant Rat PRKAA2 Protein, His (Fc)-Avi-tagged | +Inquiry |
PRKAA2-105H | Recombinant Human AMPK (combination of A2/B1/G1 subunits), His-tagged | +Inquiry |
PRKAA2-363H | Recombinant Human PRKAA2 protein, His/MBP-tagged | +Inquiry |
PRKAA2-60H | Active Recombinant Human PRKAA2 (A2/B2/G3), GST-His-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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