"RNASEH2A" Related Products


Recombinant Human RNASEH2A cell lysate

Cat.No. : RNASEH2A-1515HCL
Description : The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid
Species : Human
Size : 100 ul
Storage Buffer : 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Applications : Western Blot;
Gene Name : RNASEH2A ribonuclease H2, subunit A [ Homo sapiens ]
Official Symbol : RNASEH2A
Synonyms : RNASEH2A; ribonuclease H2, subunit A; Aicardi Goutieres syndrome 4 , ribonuclease H2, large subunit; ribonuclease H2 subunit A; AGS4; RNASEHI; RNHIA; RNHL; RNase H(35); RNase H2 subunit A; RNase HI large subunit; ribonuclease HI subunit A; ribonuclease HI large subunit; ribonuclease H2, large subunit; ribonuclease HI, large subunit; aicardi-Goutieres syndrome 4 protein; JUNB;
Gene ID : 10535
mRNA Refseq : NM_006397
Protein Refseq : NP_006388
MIM : 606034
UniProt ID : O75792
Chromosome Location : 19p13.13
Pathway : DNA replication, organism-specific biosystem; DNA replication, conserved biosystem;
Function : RNA binding; endonuclease activity; hydrolase activity; metal ion binding; ribonuclease H activity; ribonuclease activity;

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