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Recombinant Human TAP2 cell lysate

Cat.No. : TAP2-1736HCL
  • Specification
  • Gene Information
  • Related Products
Description : The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.
Species : Human
Size : 100 ul
Storage Buffer : 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Applications : Western Blot;
Gene Name : TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) [ Homo sapiens ]
Official Symbol : TAP2
Synonyms : TAP2; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP); ABCB3; antigen peptide transporter 2; D6S217E; PSF2; RING11; ABC transporter, MHC 2; peptide supply factor 2; peptide transporter PSF2; peptide transporter TAP2; really interesting new gene 11 protein; transporter 2, ABC (ATP binding cassette); peptide transporter involved in antigen processing 2; ATP-binding cassette, sub-family B (MDR/TAP), member 3; APT2; ABC18; PSF-2;
Gene ID : 6891
mRNA Refseq : NM_000544
Protein Refseq : NP_000535
MIM : 170261
UniProt ID : Q03519
Chromosome Location : 6p21.3
Pathway : ABC transporters, organism-specific biosystem; ABC transporters, conserved biosystem; Adaptive Immune System, organism-specific biosystem; Antigen Presentation: Folding, assembly and peptide loading of class I MHC, organism-specific biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Antigen processing-Cross presentation, organism-specific biosystem;
Function : ATP binding; ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances; MHC class I protein binding; TAP1 binding; TAP1 binding; TAP2 binding; nucleotide binding; oligopeptide-transporting ATPase activity; peptide antigen binding; peptide antigen-transporting ATPase activity; peptide transporter activity; contributes_to peptide transporter activity; protein binding; tapasin binding; transporter activity; transporter activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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