Recombinant Human TBX21 cell lysate

• Cat.No.: TBX21-1747HCL

Specification

• Description: This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells.
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: TBX21 T-box 21 [ Homo sapiens ]
• Official Symbol: TBX21
• Synonyms: TBX21; T-box 21; T-box transcription factor TBX21; T bet; TBLYM; T-box protein 21; T-box expressed in T cells; transcription factor TBLYM; T-cell-specific T-box transcription factor T-bet; TBET; T-PET; T-bet
• Gene ID: 30009
• mRNA Refseq: NM_013351
• Protein Refseq: NP_037483
• MIM: 604895
• UniProt ID: Q9UL17
• Chromosome Location: 17q21.2
• Pathway: Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Glucocorticoid receptor regulatory network, organism-specific biosystem; IL12 signaling mediated by STAT4, organism-specific biosystem; IL12-mediated signaling events, organism-specific biosystem; IL27-mediated signaling events, organism-specific biosystem
• Function: DNA binding; sequence-specific DNA binding transcription factor activity; transcription regulatory region DNA binding