Recombinant Human TXNRD1 cell lysate

• Cat.No.: TXNRD1-1866HCL

Specification

• Description: This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3 UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms.
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: TXNRD1 thioredoxin reductase 1 [ Homo sapiens ]
• Official Symbol: TXNRD1
• Synonyms: TXNRD1; thioredoxin reductase 1; thioredoxin reductase 1, cytoplasmic; GRIM 12; Trxr1; TXNR; oxidoreductase; thioredoxin reductase TR1; thioredoxin reductase GRIM-12; KM-102-derived reductase-like factor; gene associated with retinoic and IFN-induced mortality 12 protein; gene associated with retinoic and interferon-induced mortality 12 protein; TR; TR1; TRXR1; GRIM-12; MGC9145
• Gene ID: 7296
• mRNA Refseq: NM_001093771
• Protein Refseq: NP_001087240
• MIM: 601112
• UniProt ID: Q16881
• Chromosome Location: 12q23-q24.1
• Pathway: Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; Metabolism of nucleotides, organism-specific biosystem; Oxidative Stress, organism-specific biosystem; PPARA Activates Gene Expression, organism-specific biosystem; Pyrimidine metabolism, organism-specific biosystem
• Function: NADP binding; electron carrier activity; flavin adenine dinucleotide binding; oxidoreductase activity; protein disulfide oxidoreductase activity; thioredoxin-disulfide reductase activity