Recombinant Human MAVS cell lysate

• Cat.No.: MAVS-1909HCL

Specification

• Description: Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 (MIM 603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) and RIGI (ROBO3; MIM 608630). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK; MIM 600664) and IKKB (IKBKB; MIM 603258), which activate NFKB (see MIM 164011), or TBK1 (MIM 604834) and IKKE (IKBKE; MIM 605048), which activate IRF3 (MIM 603734). Activated IRF3 and NFKB induce transcription of IFNB (IFNB1; MIM 147640). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1; MIM 607601). For RIGI, the intermediary protein is mitochondria-bound IPS1 (Sen and Sarkar, 2005 [PubMed 16239922]).
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: MAVS mitochondrial antiviral signaling protein [ Homo sapiens ]
• Official Symbol: MAVS
• Synonyms: MAVS; mitochondrial antiviral signaling protein; mitochondrial antiviral-signaling protein; CARD adaptor inducing IFN beta; Cardif; IFN B promoter stimulator 1; IPS 1; KIAA1271; virus induced signaling adaptor; VISA; IFN-B promoter stimulator 1; CARD adaptor inducing IFN-beta; virus-induced signaling adaptor; virus-induced-signaling adapter; CARD adapter inducing interferon beta; putative NF-kappa-B-activating protein 031N; interferon beta promoter stimulator protein 1; IPS1; IPS-1; CARDIF; MGC3260; FLJ27482; FLJ31698; FLJ35386; FLJ38051; FLJ41962; DKFZp547C224; DKFZp666M015
• Gene ID: 57506
• mRNA Refseq: NM_001206491
• Protein Refseq: NP_001193420
• MIM: 609676
• UniProt ID: Q7Z434
• Chromosome Location: 20p13
• Pathway: Cytosolic DNA-sensing pathway, organism-specific biosystem; Cytosolic DNA-sensing pathway, conserved biosystem; Hepatitis C, organism-specific biosystem; Hepatitis C, conserved biosystem; Herpes simplex infection, organism-specific biosystem; Herpes simplex infection, conserved biosystem; Immune System, organism-specific biosystem
• Function: CARD domain binding; protein binding; protein kinase binding; signal transducer activity