"WHSC2" Related Products

Recombinant Human WHSC2 cell lysate

Cat.No.: WHSC2-1932HCL
Description: This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.
Species: Human
Size: 100 ul
Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Applications: Western Blot;
Gene Name: WHSC2 Wolf-Hirschhorn syndrome candidate 2 [ Homo sapiens ]
Official Symbol: WHSC2
Synonyms: WHSC2; Wolf-Hirschhorn syndrome candidate 2; negative elongation factor A; NELF A; wolf-Hirschhorn syndrome candidate 2 protein; NELFA; NELF-A; P/OKcl.15; FLJ10442; FLJ25112;
Gene ID: 7469
mRNA Refseq: NM_005663
Protein Refseq: NP_005654
MIM: 606026
UniProt ID: Q9H3P2
Chromosome Location: 4p16.3
Pathway: Abortive elongation of HIV-1 transcript in the absence of Tat, organism-specific biosystem; Disease, organism-specific biosystem; Formation of HIV-1 elongation complex containing HIV-1 Tat, organism-specific biosystem; Formation of HIV-1 elongation complex in the absence of HIV-1 Tat, organism-specific biosystem; Formation of RNA Pol II elongation complex, organism-specific biosystem; Formation of the Early Elongation Complex, organism-specific biosystem; Formation of the HIV-1 Early Elongation Complex, organism-specific biosystem;

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