Recombinant Human Activin A Receptor, Type I
Cat.No. : | ACVR1-01H |
Product Overview : | Recombinant Human Activin A Receptor, Type I was expressed in sf9. |
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Description : | Human Activin A is a 26.0 kDa disulfide-linked homodimer of two βA chains, each containing 116 amino acid residues, belonging to the TGF-β family. It exhibits a wide range of biological activity including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in postmenopausal women have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, follistatin. |
Source : | sf9 |
Species : | Human |
Form : | Liquid |
Molecular Mass : | The secreted recombinant human ALK2 consists of 123 amino acids and has a calculated molecular mass of 13.5KDa. It migrates as an approximately 17kDa band in SDS-PAGE under reducing conditions. |
AA Sequence : | MVDGVMILPVLIMIALPSPSMEDEK PKVNPKLYMCVCEGLSCGNEDHCEG QQCFSSLSINDGFHVYQKGCFQVYE QGKMTCKTPPSPGQAVECCQGDWCN RNITAQLPTKGKSFPGTQNFHLE |
Purity : | >93% as determined by SDS-PAGE. |
Storage : | Store it at +4°C for short term. For long term storage, store it at -20°C ~ -70°C. |
Storage Buffer : | 25 mM Tris-HCl, pH7.4, 300 mM NaCl ,1 mM DTT, 5% Trehalose. |
Publication : |
An anti-ACVR1 antibody exacerbates heterotopic ossification by fibro-adipogenic progenitors in fibrodysplasia ossificans progressiva mice (2022)
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Gene Name : | ACVR1 activin A receptor, type I [ Homo sapiens ] |
Official Symbol : | ACVR1 |
Synonyms : | ACVR1; activin A receptor, type I; ACVRLK2; activin receptor type-1; ACVR1A; ALK2; SKR1; activin receptor type I; hydroxyalkyl-protein kinase; activin receptor-like kinase 2; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 2; serine/threonine-protein kinase receptor R1; FOP; TSRI; ACTRI; |
Gene ID : | 90 |
mRNA Refseq : | NM_001105 |
Protein Refseq : | NP_001096 |
MIM : | 102576 |
UniProt ID : | Q04771 |
Chromosome Location : | 2q23-q24 |
Pathway : | ALK1 pathway, organism-specific biosystem; ALK1 signaling events, organism-specific biosystem; ALK2 signaling events, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; TGF-beta signaling pathway, organism-specific biosystem; TGF-beta signaling pathway, conserved biosystem; |
Function : | ATP binding; SMAD binding; activin binding; contributes_to activin receptor activity, type I; follistatin binding; metal ion binding; nucleotide binding; protein binding; protein homodimerization activity; protein serine/threonine kinase activity; receptor activity; receptor signaling protein serine/threonine kinase activity; transforming growth factor beta binding; transforming growth factor beta receptor activity, type I; transmembrane receptor protein serine/threonine kinase activity; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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