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Recombinant Cynomolgus CD3E, His-Fc-tagged

Cat.No.: CD3E-199C
Product Overview: Recombinant Cynomolgus CD3E /CD3 Epsilon Protein, C-Fc Tag (Cynomolgus CD3E Fc Chimera) Gln 22 - Asp 117 (Accession # Q95LI5) was produced in human 293 cells (HEK293).
Description: CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.
Source: HEK293
Species: Cynomolgus
Tag: His-Fc
Form: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Molecular Mass: Cynomolgus CD3E Fc Chimera is fused with polyhistidine tagged human IgG1 Fc fragment at the C-terminus, and has a calculated MW of 38.3 kDa. The predicted N-terminus is Gln 22. DTT-reduced Protein migrates as 40-50 kDa in SDS-PAGE due to glycosylation.
Endotoxin: Less than 1.0 EU per μg of the Cynomolgus CD3E Fc Chimera by the LAL method.
Purity: >95% as determined by SDS-PAGE.
Storage: Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at:In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).
Reconstitution: See Certificate of Analysis for reconstitution instructions and specific concentrations.
Gene Name: CD3E CD3e molecule, epsilon (CD3-TCR complex) [ Macaca fascicularis (crab-eating macaque) ]
Official Symbol: CD3E
Synonyms: FLJ18683, T3E, TCRE, CD3E, CD3-epsilon, CD3 epsilon, T-cell surface glycoprotein CD3 epsilon chain, CD3 epsilon FN18+, CD3 epsilon FN18-
Gene ID: 102133065
mRNA Refseq: NM_001283615.1
Protein Refseq: NP_001270544.1
UniProt ID: Mfa.6117
Pathway: Chagas disease (American trypanosomiasis), organism-specific biosystem; HTLV-I infection, organism-specific biosystem; Hematopoietic cell lineage, organism-specific biosystem; Measles, organism-specific biosystem; Primary immunodeficiency, organism-specific biosystem; T cell receptor signaling pathway, organism-specific biosystem

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