"Ifna4" Related Products


Recombinant Mouse Ifna4, Fc-tagged

Cat.No.: Ifna4-122M
Product Overview: A DNA sequence encoding the extracellular domain of mouse IFNA4 (Cys 25-Glu 186) was fused with the Fc region of human IgG1 at the N-terminus.
Description: Interferon, alpha 4 (IFNA4) belongs to the alpha/beta interferon family. Two variants of IFNA4 (IFNA4a and IFNA4b) are known, which differ from each other by changes in their coding regions at nucleotide positions 220 and 410 and can be distinguished by selective restriction enzyme analysis. Interferons are produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. IFN-alpha, the first cytokine to be produced by recombinant DNA technology, has emerged as an important regulator of growth and differentiation, affecting cellular communication and signal transduction pathways as well as immunological control. Originally discovered as an antiviral substance, the efficacy of IFN-alpha in malignant, viral, immunological, angiogenic, inflammatory, and fibrotic diseases suggests a spectrum of interrelated pathophysiologies. IFN-alpha emerged as a prototypic tumor suppressor protein that represses the clinical tumorigenic phenotype in some malignancies capable of differentiation.
Source: Human Cells
Species: Mouse
Tag: Fc
Predicted N Terminal: Glu
Form: Lyophilized from sterile PBS, pH 7.4
Bio-activity: Measured in antiviral assays using L929 cells infected with vesicular stomatitisvirus (VSV). The ED50 for this effect is typically 0.2-1 ng/mL.
Molecular Mass: The recombinant mouse IFNA4/Fc is a disulfide-linked homodimer. The reduced monomer comprises 422 amino acids and has a calculated molecular mass of 47.2 kD as estimated in SDS-PAGE under reducing conditions.
Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
Purity: >85 % as determined by SDS-PAGE
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Storage: Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products.
Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Gene Name: Ifna4 interferon alpha 4 [ Mus musculus ]
Official Symbol: Ifna4
Synonyms: Ifna4; interferon alpha 4; Ifa4; MGC143607; MuIFN-alpha 4; interferon, alpha 4; OTTMUSP00000012085; interferon alpha family, gene 4
Gene ID: 15967
mRNA Refseq: NM_010504
Protein Refseq: NP_034634
UniProt ID: P07351
Chromosome Location: 4 C4; 4 42.03 cM
Pathway: Antigen processing and presentation; Autoimmune thyroid disease; Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Natural killer cell mediated cytotoxicity; RIG-I-like receptor signaling pathway; Regulation of autophagy;
Function: cytokine activity; cytokine receptor binding; type I interferon receptor binding

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