Recombinant Human PON1, His-tagged

• Cat.No.: PON1-06H
• Product Overview: Recombinant full length human PON1 was produced from the synthetic gene with the C-terminal 6xHis tag in Trichoplusia ni larval expression system.

Specification

• Description: PON1 hydrolyzes the toxic metabolites of a broad spectrum of organophosphate substrates. PON1 mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.
• Source: Trichoplusia ni larval expression system
• Species: Human
• Tag: His
• Form: 1 mg/mL in 50 mM Tris, 200 mM NaCl, 2 mM CaCl2, 0.2 μm filtered.
• AA Sequence: MAKLIALTLL GMGLALFRNH QSSYQTRLNA LREVQPVELP NCNLVKGIET GSEDMEILPN GLAFISSGLK YPGIKSFNPN SPGKILLMDL NEEDPTVLEL GITGSKFDVS SFNPHGISTFTDEDNAMYLL VVNHPDAKST VELFKFQEEE KSLLHLKTIR HKLLPNLNDI VAVGPEHFYG TNDHYFLDPY LQSWEMYLGL AWSYVVYYSP SEVRVVAEGF DFANGINISP DGKYVYIAELLAHKIHVYEK HANWTLTPLK SLDFNTLVDN ISVDPETGDL WVGCHPNGMK IFFYDSENPP ASEVLRIQNI LTEEPKVTQV YAENGTVLQG STVASVYKGK LLIGTVFHKA LYCELHHHHHH
• Purity: >90% as determined by SDS-PAGE
• Storage: Store at -80°C or colder upon arrival. Freeze-thaw cycles of this product should be avoided.

Gene Information

• Gene Name: PON1 paraoxonase 1 [ Homo sapiens ]
• Official Symbol: PON1
• Synonyms: ESA; PON; MVCD5; serum paraoxonase/arylesterase 1; K-45; PON 1; esterase A; A-esterase 1; arylesterase 1; paraoxonase B-type; aromatic esterase 1; arylesterase B-type; serum aryldiakylphosphatase; serum aryldialkylphosphatase 1
• Gene ID: 5444
• mRNA Refseq: NM_000446
• Protein Refseq: NP_000437
• MIM: 168820
• UniProt ID: P27169
• Chromosome Location: 7q21.3
• Pathway: Metabolic pathways, organism-specific biosystem; Phase I, non P450, organism-specific biosystem
• Function: aryldialkylphosphatase activity; arylesterase activity; calcium ion binding