| Description : |
C3a is a one of the proteins formed by the cleavage of complement component 3; the other is C3b.C3a plays an important role in chemotaxis, though not as important a role as C5a.It is also an anaphylatoxin.Soluble C3-convertase, also known as C4b2a, catalyzes the proteolytic cleavage of C3 into C3a and C3b as part of the classical complement system as well as the mannan-binding lectin pathway. C3a is an anaphylotoxin, and C3b serves as an opsonizing agent. Factor I can cleave C3b into C3c and C3d, the latter of which plays a role in enhancing B cell responses. Complement Component 3a (C3a) is an essential regulatory factor and inhibiting its binding to a C3a receptor will diminish the inflammation response by disrupting the cascade. We report the design, synthesis, in vitro and in vivo activity of diiminoisoindolines as C3a antagonists. |
| Source : |
Yeast |
| Species : |
Human |
| Form : |
Lyophilized from sterile 20mM PB,240mM NaCl,PH6.0. |
| Molecular Mass : |
41.1kDa |
| Endotoxin : |
< 1.0 eu per μg of the protein as determined by the LAL method. |
| Purity : |
>95 % as determined by SDS-PAGE |
| Applications : |
Western blotting, ELISA |
| Storage : |
Store it under sterile conditions at -20℃ to -97℃ upon receiving.Recommend to aliquot the protein into smaller quantities for optimal storage. |
