Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human GP1BA, His-tagged, Single-sulfated

Cat.No. : GP1BA-21H
Product Overview : Recombinant human GP1BA, fused with an C-terminal hexahistidine tag, was expressed in HEK293-EBNA1 cells. In the native protein the tyrosine residues at positions 292, 294 and 295 are sulfated. In this product one of the three tyrosines are sulfated.
  • Specification
  • Gene Information
  • Related Products
Description : Glycoprotein Ibα is part of the platelet receptor Glycoprotein Ib-XI-V complex. The Glycoprotein Ib-XI-V complex mediates binding of platelets to sites of vascular damage. This product consists of residues 17-306 of glycoprotein Ibα and contains the binding sites for Von Willebrand Factor, thrombin and botrocetin. The two N-linked glycoslation sites , Asn37 and Asn175, have been removed by mutation to glutamine.
Source : HEK293-EBNA1 cells
Species : Human
Tag : His
Form : PBS without preservative.
Molecular Mass : The calculated molecular weight is 33.5 kDa.
Storage : - 80 °C (stable for at least 1 year). After thawing it should be stored in appropriate small aliquots at - 20 °C or - 80 °C (stable for at least 2 months).
Gene Name : GP1BA glycoprotein Ib (platelet), alpha polypeptide [ Homo sapiens ]
Official Symbol : GP1BA
Synonyms : GP1BA; glycoprotein Ib (platelet), alpha polypeptide; GP1B; platelet glycoprotein Ib alpha chain; CD42b; GP-Ib alpha; antigen CD42b-alpha; platelet membrane glycoprotein 1b-alpha subunit; BSS; VWDP; CD42B; GPIbA; BDPLT1; BDPLT3; DBPLT3; CD42b-alpha; MGC34595;
Gene ID : 2811
mRNA Refseq : NM_000173
Protein Refseq : NP_000164
MIM : 606672
UniProt ID : P07359
Chromosome Location : 17pter-p12
Pathway : ECM-receptor interaction, organism-specific biosystem; ECM-receptor interaction, conserved biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem; GP1b-IX-V activation signalling, organism-specific biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem; Hemostasis, organism-specific biosystem;
Function : protein binding; thrombin receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (7)

Ask a question
What is the primary function of Glycoprotein Ib platelet subunit alpha (GP1BA) in platelet physiology and hemostasis? 05/05/2022

Glycoprotein Ib platelet subunit alpha (GP1BA) plays a crucial role in platelet physiology and hemostasis, specifically in platelet adhesion.

What diseases or conditions are associated with dysregulation or abnormal expression of GP1BA? 11/24/2021

Dysregulation or abnormal expression of GP1BA is associated with conditions such as Bernard-Soulier syndrome and other platelet disorders.

How does GP1BA contribute to platelet adhesion and the formation of platelet plugs at sites of vascular injury? 12/03/2020

GP1BA contributes to platelet adhesion by interacting with von Willebrand factor (vWF), facilitating platelet plug formation at vascular injury sites.

What are the interactions or binding partners of GP1BA, and how do they influence platelet function? 08/13/2020

Interactions or binding partners of GP1BA include vWF and other components of the platelet glycoprotein Ib-IX-V complex, influencing platelet function.

How does GP1BA participate in the regulation of blood clotting and coagulation cascades? 01/06/2019

GP1BA participates in the regulation of blood clotting and coagulation cascades by initiating platelet activation and aggregation.

In which cellular compartments is GP1BA predominantly localized, especially within platelets? 08/24/2018

GP1BA is predominantly localized on the surface of platelets, especially within the platelet membrane.

Are there therapeutic implications or potential targets related to GP1BA in diseases involving platelet disorders? 03/06/2018

There are potential therapeutic implications related to GP1BA in diseases involving platelet disorders, making it a target for drug development.

Customer Reviews (3)

Write a review
Reviews
11/04/2022

    Its compatibility with collaborative platforms and open-source tools facilitated sharing and reproducibility of our experiments.

    04/12/2022

      The product's support in the form of educational resources positively impacted the learning curve for our researchers.

      06/24/2016

        The product's track record of being featured in influential publications positively influenced our decision to use it.

        Ask a Question for All GP1BA Products

        Required fields are marked with *

        My Review for All GP1BA Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends