Recombinant Mouse Il6st protein, His-tagged
Cat.No. : | Il6st-173M |
Product Overview : | Recombinant Mouse Il6st (Gln23-Glu617) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293). |
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Description : | Interleukin-6 receptor subunit beta (IL6ST) is also known as IL-6 receptor subunit beta, IL-6R subunit beta, IL-6R-beta, IL-6RB, Interleukin-6 signal transducer, Membrane glycoprotein 130 (gp130), CD130, Oncostatin-M receptor subunit alpha and Il6st,which is single-pass type I membrane protein. IL6ST /gp130/CD130 can be found in tissues such as brain, heart, thymus, spleen, kidney, lung and liver and found in all the cell lines tested except BaF-B03.The expression of IL-6ST/gp130 is not restricted to IL6-responsive cells. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. IL6ST/CD130 can bind to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduce the signal. IL6ST/GP130 does not bind IL6 and may have a role in embryonic development. |
Source : | HEK293 |
Species : | Mouse |
Tag : | His |
Predicted N Terminal : | Gln23 |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 68.5 kDa. The protein migrates as 85-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | Gln23-Glu617 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Publication : |
Effect of (−)-Epigallocatechin Gallate on Activation of JAK/STAT Signaling Pathway by Staphylococcal Enterotoxin A (2021)
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Gene Name : | Il6st |
Official Symbol : | Il6st |
Synonyms : | IL6ST; interleukin 6 signal transducer; interleukin-6 receptor subunit beta; IL-6RB; IL-6R-beta; IL-6R subunit beta; membrane glycoprotein 130; IL-6 receptor subunit beta; interleukin-6 signal transducer; oncostatin-M receptor subunit alpha; CD130; gp130; AA389424; BB405851; D13Ertd699e; 5133400A03Rik |
Gene ID : | 16195 |
mRNA Refseq : | NM_010560 |
Protein Refseq : | NP_034690 |
UniProt ID : | Q00560 |
Products Types
◆ Recombinant Protein | ||
Il6st-274M | Recombinant Mouse Il6st Protein, His-tagged | +Inquiry |
IL6ST-1380H | Acitve Recombinant Human IL6ST protein(Met1-Ile618), His&hFc-tagged | +Inquiry |
IL6ST-2749H | Recombinant Human IL6ST protein(771-910 aa), C-His-tagged | +Inquiry |
IL6ST-1055H | Recombinant Human IL6ST Protein, His-tagged | +Inquiry |
Il6st-26R | Recombinant Rat Il6st Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
IL6ST-001MCL | Recombinant Mouse IL6ST cell lysate | +Inquiry |
IL6ST-946CCL | Recombinant Cynomolgus IL6ST cell lysate | +Inquiry |
IL6ST-935HCL | Recombinant Human IL6ST cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThe activity of IL6ST is usually detected by cell differentiation and proliferation assay.
IL6ST may be used in the future to treat pulmonary fibrosis, chronic pulmonary obstruction, rheumatoid arthritis, and other chronic kidney diseases.
IL6ST is involved in various inflammatory responses and cell differentiation processes.
The physical and chemical properties of IL6ST include molecular weight, voltammetry potential, structure and stability.
The study of IL6ST helps us to better understand the disease mechanism involved in IL6ST, and provides new ideas and means for disease treatment.
The IL6ST is usually prepared by transforming E. coli into an expression vector and making it express the IL6ST protein.
Customer Reviews (3)
Write a reviewIL6ST proteins can be functionally enhanced or altered by protein modification techniques.
As an immunotherapy drug, it has good effect and high safety.
Has a good inhibitory effect on cell proliferation and survival.
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