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Recombinant Mouse Il6st, His-tagged

Cat.No.: Il6st-173M
Product Overview: Recombinant Mouse IL6ST /GP130 /CD130 Protein (Mouse IL6ST /GP130 /CD130) Gln 23 - Glu 617 (Accession # NP_034690) was produced in human 293 cells (HEK293).
Description: Interleukin-6 receptor subunit beta (IL6ST) is also known as IL-6 receptor subunit beta, IL-6R subunit beta, IL-6R-beta, IL-6RB, Interleukin-6 signal transducer, Membrane glycoprotein 130 (gp130), CD130, Oncostatin-M receptor subunit alpha and Il6st,which is single-pass type I membrane protein. IL6ST /gp130 /CD130 can be found in tissues such as brain, heart, thymus, spleen, kidney, lung and liver and found in all the cell lines tested except BaF-B03.The expression of IL-6ST /gp130 is not restricted to IL6-responsive cells. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. IL6ST /CD130 can bind to IL6 /IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduce the signal. IL6ST /GP130 does not bind IL6 and may have a role in embryonic development.
Source: HEK293
Species: Mouse
Tag: His
Predicted N Terminal: Gln 23
Form: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Molecular Mass: Mouse IL6ST /GP130 /CD130 is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 68.5 kDa. The predicted N-terminus is Gln 23. DTT-reduced Protein migrates as 85-100 kDa in SDS-PAGE due to glycosylation.
Endotoxin: Less than 1.0 EU per μg of the Mouse IL6ST /GP130 /CD130 by the LAL method.
Purity: >95% as determined by SDS-PAGE.
Applications: CD Antigens
Storage: Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at:In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).
Gene Name: Il6st interleukin 6 signal transducer [ Mus musculus ]
Official Symbol: Il6st
Synonyms: IL6ST; interleukin 6 signal transducer; interleukin-6 receptor subunit beta; IL-6RB; IL-6R-beta; IL-6R subunit beta; membrane glycoprotein 130; IL-6 receptor subunit beta; interleukin-6 signal transducer; oncostatin-M receptor subunit alpha; CD130; gp130; AA389424; BB405851; D13Ertd699e; 5133400A03Rik;
Gene ID: 16195
mRNA Refseq: NM_010560
Protein Refseq: NP_034690
Pathway: Adipogenesis, organism-specific biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; ESC Pluripotency Pathways, organism-specific biosystem; IL-6 signaling Pathway, organism-specific biosystem; Jak-STAT signaling pathway, organism-specific biosystem;
Function: ciliary neurotrophic factor receptor activity; ciliary neurotrophic factor receptor binding; growth factor binding; contributes_to interleukin-11 binding; contributes_to interleukin-11 receptor activity; interleukin-6 receptor activity; protein binding; p

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