"Fcgr1" Related Products


Recombinant Mouse Fcgr1, His-Avi-tagged, Biotinylated

Cat.No.: Fcgr1-190M
Product Overview: Biotinylated Mouse CD64 /FCGR1A Protein, His Tagged Avi Tag (Biotinylated Mouse CD64 /FCGR1A,His.Avi Tag) Glu 25 - Pro 297 (Accession # NP_034316) was produced in human 293 cells (HEK293).
Description: Receptors that recognize the Fc portion of IgG are divided into three groups designated Fc gamma RI, RII, and RIII, also known respectively as CD64, CD32, and CD16. Fc gamma RI binds IgG with high affinity and functions during early immune responses. Fc gamma RII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses. High affinity immunoglobulin gamma Fc receptor I is also known as FCGR1A, FCG1, FCGR1, CD64 and IGFR1, is a type of integral membrane glycoprotein that binds monomeric IgG-type antibodies with high affinity, which belongs to the immunoglobulin superfamily or FCGR1 family. FCGR1A / CD64 contains 3 Ig-like C2-type (immunoglobulin-like) domains. CD64 is constitutively found on only macrophages and monocytes, but treatment of polymorphonuclear leukocytes with cytokines like IFNγ and G-CSF can induce CD64 expression on these cells.
Source: HEK293
Species: Mouse
Tag: His-Avi
Predicted N Terminal: Glu 25
Form: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Molecular Mass: Biotinylated Mouse CD64 /FCGR1A,His.Avi Tag is fused with polyhistidine tagged Avi tag at the C-terminus, and has a calculated MW of 33 kDa. The predicted N-terminus is Glu 25. DTT-reduced Protein migrates as 45-60 kDa in SDS-PAGE due to glycosylation.By
Endotoxin: Less than 1.0 EU per μg of the Biotinylated Mouse CD64 /FCGR1A,His.Avi Tag by the LAL method.
Purity: >92% as determined by SDS-PAGE.
Applications: Biotin Labeled Protein
Storage: Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at:In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).
Gene Name: Fcgr1 Fc receptor, IgG, high affinity I [ Mus musculus ]
Official Symbol: Fcgr1
Synonyms: FCGR1; Fc receptor, IgG, high affinity I; high affinity immunoglobulin gamma Fc receptor I; fcRI; fc-gamma RI; igG Fc receptor I; IgG high affinity Fc receptor; CD64; IGGHAFC; AI323638; AV092959; FcgammaRI;
Gene ID: 14129
mRNA Refseq: NM_010186
Protein Refseq: NP_034316
Pathway: Fc gamma R-mediated phagocytosis, organism-specific biosystem; Fc gamma R-mediated phagocytosis, conserved biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem; Leishmaniasis, organism-specific biosystem; Leishmaniasis, conserved biosystem; Osteoclast differentiation, organism-specific biosystem;
Function: IgG binding; IgG binding; IgG receptor activity; receptor activity;

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