Recombinant Human FASN, GST-tagged
Cat.No. : | FASN-21H |
Product Overview : | Recombinant Human FASN(2378 a.a. - 2477 a.a.), fused with GST-tag at N-terminal, was expressed in wheat germ. |
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Description : | The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. |
Source : | Wheat germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 36.74 kDa |
AA Sequence : | MEHNRVLEALLPLKGLEERVAAAVD LIIKSHQGLDRQELSFAARSFYYKL RAAEQYTPKAKYHGNVMLLRAKTGG AYGEDLGADYNLSQVCDGKVSVHVI |
Applications : | ELISA; WB-Re; AP; Array |
Storage : | Store at -80°C. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | FASN fatty acid synthase [ Homo sapiens ] |
Official Symbol : | FASN |
Synonyms : | FASN; fatty acid synthase; FAS; SDR27X1; short chain dehydrogenase/reductase family 27X; member 1; |
Gene ID : | 2194 |
mRNA Refseq : | NM_004104 |
Protein Refseq : | NP_004095 |
MIM : | 600212 |
UniProt ID : | P49327 |
Chromosome Location : | 17q25 |
Pathway : | AMPK signaling; Activation of gene expression by SREBF (SREBP); Defective AMN causes hereditary megaloblastic anemia 1 |
Function : | 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity; 3-oxoacyl-[acyl-carrier-protein] synthase activity; [acyl-carrier-protein] S-acetyltransferase activity |
Products Types
◆ Recombinant Protein | ||
FASN-0482H | Recombinant Human FASN Protein (Q1109-G1524), His tagged | +Inquiry |
FASN-3121M | Recombinant Mouse FASN Protein, His (Fc)-Avi-tagged | +Inquiry |
Fasn-720R | Recombinant Rat Fasn Protein, His-tagged | +Inquiry |
FASN-0481H | Recombinant Human FASN Protein (Q1109-G1524), Tag Free | +Inquiry |
Fasn-719M | Recombinant Mouse Fasn Protein, His-tagged | +Inquiry |
◆ Lysates | ||
FASN-597HCL | Recombinant Human FASN cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, several clinical trials are investigating FASN inhibitors as potential treatments for cancer and metabolic disorders.
FASN has been associated with insulin resistance, and its inhibition is being investigated as a potential avenue for treating insulin resistance and type 2 diabetes.
Combination therapies involving FASN inhibitors and other anticancer drugs are being explored to enhance treatment efficacy and reduce potential resistance.
FASN is involved in the synthesis of fatty acids, and its dysregulation can contribute to excessive fat accumulation, potentially leading to obesity.
Emerging research suggests a potential link between FASN and neurodegenerative diseases, but more studies are needed to fully understand this connection.
Customer Reviews (3)
Write a reviewIts high quality and purity ensure accurate and reliable results.
With the manufacturer's unwavering dedication to delivering quality products and unparalleled technical support, I am confident in their ability to help me overcome any challenges and propel my research forward.
The FASN protein exhibits several valuable attributes that make it an excellent choice for my trials.
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