Recombinant Human EGLN1, MYC/DDK-tagged


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Recombinant Human EGLN1, MYC/DDK-tagged

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Cat.No. : EGLN1-127H
Product Overview : Recombinant Human EGLN1, fused with C-terminal MYC/DDK, was expressed in HEK293 cells.
Description : The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3).
Source : HEK293 cells
Species : Human
Molecular Mass : 45.8 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : EGLN1 egl-9 family hypoxia-inducible factor 1 [ Homo sapiens (human) ]
Official Symbol : EGLN1
Synonyms : EGLN1; egl nine homolog 1 (C. elegans); C1orf12, EGL nine (C.elegans) homolog 1; egl nine homolog 1; HIF prolyl hydroxylase 2; HIFPH2; PHD2; SM 20; ZMYND6; egl nine-like protein 1; HIF-prolyl hydroxylase 2; zinc finger MYND domain-containing protein 6; hypoxia-inducible factor prolyl hydroxylase 2; prolyl hydroxylase domain-containing protein 2; HPH2; SM20; ECYT3; HPH-2; C1orf12; HIF-PH2; DKFZp761F179
Gene ID : 54583
mRNA Refseq : NM_022051
Protein Refseq : NP_071334
MIM : 606425
UniProt ID : Q9GZT9
Chromosome Location : 1q42.1
Pathway : Cellular response to hypoxia; HIF-1 signaling pathway; HIF-2-alpha transcription factor network
Function : L-ascorbic acid binding; peptidyl-proline 4-dioxygenase activity; peptidyl-proline dioxygenase activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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