Recombinant Human ATAD2, His&Flag-tagged

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Recombinant Human ATAD2, His&Flag-tagged

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Cat.No. : ATAD2-31H
Product Overview : Recombinant Human ATAD2 corresponding to amino acids 981 - 1108 that contains the bromodomain sequences of ATAD2 (accession number NP_054828.2) was expressed in E. coli and contains an N-terminal His tag and C-terminal FLAG tag.
Description : ATPase family AAA domain-containing 2 (ATAD2) protein belongs to the AAA protein family which includes a diverse set of proteins with the capacity to couple ATPase-derived chemical energy to mechanical energy resulting in remodeling or translocation of the targeted macromolecular substrate. These proteins are involved in a number of cellular processes ranging from protein degradation and DNA replication to membrane fusion and the movement of microtubule motors. ATAD2 is thought to act as a transcriptional coactivator of the nuclear receptor ESR1 that is required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. Furthermore, ATAD2 may also play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. In addition, there is evidence that ATAD2 may be required for histone hyperacetylation. Human ATAD2 consists of two AAA+ domains and a bromodomain. Bromodomains recognize acetylated histone lysine residues and function as "readers" of these epigenetic histone marks to regulate chromatin structure and gene expression by linking associated proteins to the recognized acetylated nucleosomal targets. The ATAD2 bromodomain specifically interacts with H4K5ac and may contribute to cancer cell proliferation since it has been associated with poor prognosis in breast and testicular cancer.
Source : E. coli
Species : Human
Tag : His&FLAG
Form : 25 mM HEPES pH 7.5, 150 mM NaCl and 5% glycerol.
Bio-activity : Binding specificity for acetylated H3K14.
Molecular Mass : 21.317 kDa
Applications : Binding assays, inhibitor screening, and selectivity profiling.
Storage : Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Concentration : 0.75 mg/ml
Gene Name : ATAD2 ATPase family, AAA domain containing 2 [ Homo sapiens ]
Official Symbol : ATAD2
Synonyms : ATAD2; ATPase family, AAA domain containing 2; ATPase family AAA domain-containing protein 2; DKFZp667N1320; MGC5254; MGC29843; PRO2000; AAA nuclear coregulator cancer-associated protein; ANCCA; MGC131938; MGC142216;
Gene ID : 29028
mRNA Refseq : NM_014109
Protein Refseq : NP_054828
MIM : 611941
UniProt ID : Q6PL18
Chromosome Location : 8q24.13
Function : ATP binding; ATPase activity; hydrolase activity; nucleotide binding;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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