Recombinant Human BRDT, His&FLAG-tagged

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Recombinant Human BRDT, His&FLAG-tagged

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Cat.No. : BRDT-37H
Product Overview : Recombinant Human BRDT corresponding to amino acids 21-137 that contains the bromodomain sequences of BRDT (accession number NP_001717.2) was expressed in E. coli and contains an N-terminal His tag and C-terminal FLAG tag.
Description : BRDT is similar to the RING3 protein family. It possesses two bromodomain motifs and a PEST sequence (a cluster of proline, glutamic acid, serine, and threonine residues), characteristic of proteins that undergo rapid intracellular degradation. The bromodomain functions as a "reader" of epigenetic histone marks and regulates chromatin structure and gene expression by linking associated proteins to the recognized acetylated nucleosomal targets.
Source : E. coli
Species : Human
Tag : His&FLAG
Form : 25 mM HEPES pH 7.5, 150 mM NaCl and 5% glycerol.
Bio-activity : Binding specificity for acetylated H2BK12/15, H3K9/14/18/23, H4K12, H4K5/8, H4K8/12, H4K12/16, H4K5/12, H4K5/8/12/16 and H4K5/8/12/16.
Molecular Mass : 20 kDa
Applications : Binding assays, inhibitor screening, and selectivity profiling.
Storage : Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Concentration : 1.9 mg/ml
Gene Name : BRDT bromodomain, testis-specific [ Homo sapiens ]
Official Symbol : BRDT
Synonyms : BRDT; bromodomain, testis-specific; bromodomain testis-specific protein; BRD6; cancer/testis antigen 9; CT9; RING3-like protein;
Gene ID : 676
mRNA Refseq : NM_001242805
Protein Refseq : NP_001229734
MIM : 602144
UniProt ID : Q58F21
Chromosome Location : 1p22.1
Function : histone binding; protein serine/threonine kinase activity; transcription coactivator activity;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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