Native Human Bacterial/Permeability-Increasing Protein

• Cat.No.: BPI-182H

Specification

• Description: Bacterial/Permeability-Increasing Protein (BPI) is present in the azurophilic granules of polymorphonuclear leukocytes (PMN). BPI is toxic only toward Gram-negative bacteria. This specificity is attributable to the strong attraction of BPI for the lipopolysaccharides (LPS) in the bacterial envelope. BPI is also an important antigen for anti-neutrophil cytoplasmic autoantibodies (ANCA) in vasculitis.
• Source: Human Whole Blood
• Species: Human
• Form: Frozen
• Molecular Mass: MW: 55,000
• Purity: >95% by SDS-PAGE
• Usage: For research use or for use in further manufacturing.
• Quality Control Test: Shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
• Stability: >1 year
• Storage: <=>
• Storage Buffer: 80 mM Citrate Phosphate, pH 5.6 , 0.75 M NaCl

Gene Information

• Gene Name: BPI bactericidal/permeability-increasing protein [ Homo sapiens ]
• Official Symbol: BPI
• Synonyms: BPI; bactericidal/permeability-increasing protein; bactericidal permeability-increasing protein; BPI fold containing family D; member 1; BPIFD1; CAP 57; recombinant BPI holoprotein, rBPI; BPI fold containing family D, member 1; rBPI
• Gene ID: 671
• mRNA Refseq: NM_001725
• Protein Refseq: NP_001716
• MIM: 109195
• UniProt ID: P17213
• Chromosome Location: 20q11.23
• Function: Gram-negative bacterial cell surface binding; lipid binding; lipopolysaccharide binding