Active Native Human Cathepsin L

• Cat.No.: CTSL-191H

Specification

• Species: Human
• Source: Human Liver
• Tag: Non
• Description: The most powerful of the lysosomal proteases. It has a higher specific activity than cathepsin B and H in the degradation of a variety of physiological protein substrates. The level of cathepsin L is a strong predictor of relapse and survival following treatment of a primary breast tumor.
• Form: Frozen
• Bio-activity: Greater than or equal to 0.5 U/mg. One unit is de ned as the amount of enzyme which hydrolyzes one umole of Z-Phe-Arg-AFC per minuteat 25°C in 400 mM Na acetate, pH 5.5 with 4 mM EDTA and 8 mM DTT.
• Molecular Mass: 25,000-29,000
• Usage: For research use or for use in further manufacturing.
• Quality Control Test: Shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
• Stability: >1 year
• Storage: <=>
• Storage Buffer: 20 mM malonate bu er, pH 5.5, with 1 mM EDTA, and 400 mM NaCl

Gene Information

• Gene Name: CTSL cathepsin L [ Homo sapiens ]
• Official Symbol: CTSL
• Synonyms: MEP; CATL; CTSL1; cathepsin L1; major excreted protein
• Gene ID: 1514
• mRNA Refseq: NM_001257971
• Protein Refseq: NP_001244900
• MIM: 116880
• UniProt ID: P07711
• Chromosome Location: 9q21.33
• Pathway: Adaptive Immune System, organism-specific biosystem; Antigen processing and presentation, conserved biosystem
• Function: collagen binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity