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Native Bovine Activated Protein C

Cat.No.: PROC-272B
Description: Activated protein C (APC) is an anticoagulant serine protease derived from the two chain, vitamin K-dependent zymogen, protein C. A complex between alpha-thrombin and thrombomodulin catalyzes a single cleavage at Arg-12 (Arg-14 in bovine) in the heavy chain of protein C, to generate activated Protein C. Several non-physiologically relevant proteases such as RVV-X activator, trypsin, and PROTAC are also capable of activating protein C. APC functions as an anticoagulant which catalyzes the proteolytic inactivation of the cofactors, factors Va and VIIIa, leading to inhibition of the prothrombinase and factor Xase complexes. The inactivation of factors Va and VIIIa is both Ca2+ and phospholipid dependent. The vitamin K dependent cofactor, protein S, moderately increases this rate of inactivation by forming a 1:1 complex with APC (Kd=6x10-9M).
Source: Plasma
Species: Bovine
Form: 50% (vol/vol) glycerol/H2O
Bio-activity: Chromogenic assay
Molecular Mass: 52650
Purity: >95% by SDS-PAGE. NOT tissue/cell culture grade. Not tested for endotoxin.
Characteristic: Extinction coefficient:13.7, Isoelectric point:4.2-4.5, Percent carbohydrate:0.14, Structure:two chains, Mr=35,000 and 21,000, disulfide linked, NH2-terminal gla domain two EGF domains
Storage: -20°C
Gene Name: PROC protein C (inactivator of coagulation factors Va and VIIIa) [ Bos taurus ]
Official Symbol: PROC
Synonyms: vitamin K-dependent protein C; autoprothrombin IIA; anticoagulant protein C; blood coagulation factor XIV
Gene ID: 281428
mRNA Refseq: NM_001166512
Protein Refseq: NP_001159984
Chromosome Location: 2q12
Pathway: Cell surface interactions at the vascular wall, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem
Function: calcium ion binding; serine-type endopeptidase activity

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