Native MFG-E8
Cat.No. : | MFGE8-289B |
- Specification
- Gene Information
- Related Products
Description : | Lactadherin is a widely distributed glycoprotein (~ 50 kDa), which was originally characterized due to its association with milk fat/lipid globule membranes. Synonymous names are PAS-6/7, bovine-associated mucoprotein, BA-46, P47, and MFG-E8. Structural hallmarks of lactadherin are the presence of two epidermal growth factor (EGF) homology domains (with an RGD peptide motif in the second EGF domain), and two C domains sharing homology with the discoidin family of lectin domains including the phospholipid-binding domains of blood clotting factors V and VIII. Lactadherin shows preferential binding to phosphatidylserine (L-form) in a calcium independent manner. |
Source : | Milk, also secreted by stimulated macrophages, vascular smooth muscle, endothelial cells |
Species : | Bovine |
Form : | TBS, 1% BSA, 0.02% azide, pH 7.4 |
Molecular Mass : | 52 kDa and 47 kDa |
Purity : | >95% by SDS-PAGE. NOT tissue/cell culture grade. Not tested for endotoxin. |
Characteristic : | Extinction coefficient:16.5, Plasma concentration: unknown in normal adults, measurable in women with metastatic breast cancer, measurable in newborn calves after milk meal, Percent carbohydrate: 6%, 13% for glycosylation variants, Structure:single chain with two EGF domains and two C domains. The mouse isoform contains a central proline rich region and the human molecule contains a single EGF domain |
Storage : | 4°C |
Gene Name : | MFGE8 milk fat globule-EGF factor 8 protein [ Bos taurus ] |
Official Symbol : | MFGE8 |
Synonyms : | lactadherin; BP47; MFGM; SED1; MFG-E8; MGP57/53; components 15/16; PAS-6/PAS-7 glycoprotein; sperm surface protein SP47 |
Gene ID : | 281913 |
mRNA Refseq : | NM_176610 |
Protein Refseq : | NP_788783 |
UniProt ID : | Q95114 |
Chromosome Location : | chromosome: 21 |
Pathway : | Amyloids, organism-specific biosystem; Disease, organism-specific biosystem |
Products Types
◆ Recombinant Protein | ||
MFGE8-1775H | Recombinant Human MFGE8 Protein, His&GST-tagged | +Inquiry |
Mfge8-4056M | Recombinant Mouse Mfge8 Protein, Myc/DDK-tagged | +Inquiry |
MFGE8-1242H | Recombinant Human MFGE8 Protein, MYC/DDK-tagged | +Inquiry |
MFGE8-3466H | Recombinant Human MFGE8 Protein, His (Fc)-Avi-tagged | +Inquiry |
Mfge8-5514M | Recombinant Mouse Mfge8 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Native Protein | ||
MFGE8-8518B | Native Bovine MFGE8, Fluoresence-labeled | +Inquiry |
MFGE8-288B | Native Bovine Lactadherin | +Inquiry |
◆ Lysates | ||
MFGE8-422HCL | Recombinant Human MFGE8 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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- Q&As
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Q&As (6)
Ask a questionThe structure of MFGE8 determines its ability and stability to bind to other proteins. The study of its structure can help us understand its function and mechanism of action.
MFGE8 can interact with a variety of other proteins, including Caspase-3, Caspase-8, EGFR, etc. These interactions enable it to regulate processes such as apoptosis, signal transduction, and cell adhesion.
Future studies of MFGE8 may focus on the following aspects: its structure-function relationship, mechanisms of interaction with other proteins, regulatory mechanisms in cells, and potential therapeutic applications. At the same time, the study of MFGE8's interaction with specific signal transduction pathways and its regulatory effect on cell growth and differentiation will also become one of the future research priorities.
Therapeutic strategies for MFGE8 may include regulating its expression level, inhibiting its interaction with other proteins, and promoting or inhibiting its function. These methods may have potential applications in the treatment of cancer, neurodegenerative diseases, and autoimmune diseases.
In neurodegenerative diseases, MFGE8 may influence the survival and death processes of neurons by regulating apoptosis and signal transduction. It could be a potential target for the treatment of neurodegenerative diseases.
Drug development against MFGE8 needs to consider its specificity, safety, pharmacokinetic properties, and potential side effects. In addition, issues such as the dosage form, route of administration and design of clinical trials need to be considered.
Customer Reviews (3)
Write a reviewIt has high application effect and safety in clinical treatment.
MFGE8 has a high resolution in Western blots, which can distinguish similar protein molecular weights.
Good stability and activity retention during long-term storage.
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