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Native MFG-E8

Cat.No. : MFGE8-289B
  • Specification
  • Gene Information
  • Related Products
Description : Lactadherin is a widely distributed glycoprotein (~ 50 kDa), which was originally characterized due to its association with milk fat/lipid globule membranes. Synonymous names are PAS-6/7, bovine-associated mucoprotein, BA-46, P47, and MFG-E8. Structural hallmarks of lactadherin are the presence of two epidermal growth factor (EGF) homology domains (with an RGD peptide motif in the second EGF domain), and two C domains sharing homology with the discoidin family of lectin domains including the phospholipid-binding domains of blood clotting factors V and VIII. Lactadherin shows preferential binding to phosphatidylserine (L-form) in a calcium independent manner.
Source : Milk, also secreted by stimulated macrophages, vascular smooth muscle, endothelial cells
Species : Bovine
Form : TBS, 1% BSA, 0.02% azide, pH 7.4
Molecular Mass : 52 kDa and 47 kDa
Purity : >95% by SDS-PAGE. NOT tissue/cell culture grade. Not tested for endotoxin.
Characteristic : Extinction coefficient:16.5, Plasma concentration: unknown in normal adults, measurable in women with metastatic breast cancer, measurable in newborn calves after milk meal, Percent carbohydrate: 6%, 13% for glycosylation variants, Structure:single chain with two EGF domains and two C domains. The mouse isoform contains a central proline rich region and the human molecule contains a single EGF domain
Storage : 4°C
Gene Name : MFGE8 milk fat globule-EGF factor 8 protein [ Bos taurus ]
Official Symbol : MFGE8
Synonyms : lactadherin; BP47; MFGM; SED1; MFG-E8; MGP57/53; components 15/16; PAS-6/PAS-7 glycoprotein; sperm surface protein SP47
Gene ID : 281913
mRNA Refseq : NM_176610
Protein Refseq : NP_788783
UniProt ID : Q95114
Chromosome Location : chromosome: 21
Pathway : Amyloids, organism-specific biosystem; Disease, organism-specific biosystem

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Is there a relationship between MFGE8's structure and function? 01/13/2023

The structure of MFGE8 determines its ability and stability to bind to other proteins. The study of its structure can help us understand its function and mechanism of action.

Does MFGE8 interact with other proteins? 11/16/2022

MFGE8 can interact with a variety of other proteins, including Caspase-3, Caspase-8, EGFR, etc. These interactions enable it to regulate processes such as apoptosis, signal transduction, and cell adhesion.

What will future research on MFGE8 focus on? 05/18/2022

Future studies of MFGE8 may focus on the following aspects: its structure-function relationship, mechanisms of interaction with other proteins, regulatory mechanisms in cells, and potential therapeutic applications. At the same time, the study of MFGE8's interaction with specific signal transduction pathways and its regulatory effect on cell growth and differentiation will also become one of the future research priorities.

What are the treatment strategies for MFGE8? 07/29/2021

Therapeutic strategies for MFGE8 may include regulating its expression level, inhibiting its interaction with other proteins, and promoting or inhibiting its function. These methods may have potential applications in the treatment of cancer, neurodegenerative diseases, and autoimmune diseases.

Does MFGE8 have a role in neurodegenerative diseases? 07/07/2021

In neurodegenerative diseases, MFGE8 may influence the survival and death processes of neurons by regulating apoptosis and signal transduction. It could be a potential target for the treatment of neurodegenerative diseases.

What factors should be considered in drug development for MFGE8? 08/25/2020

Drug development against MFGE8 needs to consider its specificity, safety, pharmacokinetic properties, and potential side effects. In addition, issues such as the dosage form, route of administration and design of clinical trials need to be considered.

Customer Reviews (3)

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Reviews
08/08/2022

    It has high application effect and safety in clinical treatment.

    10/08/2021

      MFGE8 has a high resolution in Western blots, which can distinguish similar protein molecular weights.

      11/09/2020

        Good stability and activity retention during long-term storage.

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