Active Recombinant Human STAMBP, GST-tagged
Cat.No. : | STAMBP-167H |
Product Overview : | Recombinant human STAMBP (amino acid residues 252-424), fused with N-terminal GST, was expressed in E.coli. |
- Specification
- Gene Information
- Related Products
Description : | AMSH is a member of the JAB1/MPN/Mov34 metalloenzyme (JAMM) family and cloning of the human gene was first described by Tanaka et al. (1999). AMSH and AMSH-LP share 54% identity and 75% sequence similarity in their JAMM domain. It is known that both proteins act as regulators of free ubiquitin in the cell, bind clathrin, and contain a putative nuclear localization signal and a microtubule interacting and transport (MIT) domain. AMSH also contains a Src homology 3 (SH3) domain, facilitating its interaction with signal transducing adaptor molecule (STAM), while this functional SH3-binding motif is lost in AMSH-LP (Davies, et al., 2011). |
Source : | E. coli |
Species : | Human |
Tag : | GST |
Form : | 50 mM HEPES pH 7.5, 150 mM sodium chloride, 2 mM dithiothreitol, 10% glycerol |
Bio-activity : | The activity of GST-AMSH CD(252-424) was validated by the monitoring of mono-ubiquitin generation as a result of the enzyme catalysed cleavage of K63-linked di-ubiquitin. Incubation of the substrate in the presence or absence of GST-AMSH CD(252-424) was compared confirming the deubiquitylating activity of GST-AMSH CD(252-424). |
Molecular Mass : | 47.1 kDa |
Purity : | >89% by SDS-PAGE |
Storage : | 12 months at -70°C. Avoid multiple freeze/thaw cycles. |
Concentration : | 0.5 mg/ml |
Gene Name : | STAMBP STAM binding protein [ Homo sapiens ] |
Official Symbol : | STAMBP |
Synonyms : | STAMBP; STAM binding protein; STAM-binding protein; AMSH; endosome-associated ubiquitin isopeptidase; associated molecule with the SH3 domain of STAM; MGC126516; MGC126518; |
Gene ID : | 10617 |
mRNA Refseq : | NM_006463 |
Protein Refseq : | NP_006454 |
MIM : | 606247 |
UniProt ID : | O95630 |
Chromosome Location : | 2p24.3-p24.1 |
Pathway : | Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Internalization of ErbB1, organism-specific biosystem; |
Function : | metal ion binding; metallopeptidase activity; peptidase activity; protein binding; |
Products Types
◆ Recombinant Protein | ||
STAMBP-0340H | Recombinant Human STAMBP Protein (S2-R424), His tagged | +Inquiry |
STAMBP-671H | Recombinant Human STAMBP Protein, His-tagged | +Inquiry |
STAMBP-4323R | Recombinant Rhesus Macaque STAMBP Protein, His (Fc)-Avi-tagged | +Inquiry |
Stambp-672M | Recombinant Mouse Stambp Protein, His-tagged | +Inquiry |
STAMBP-8776M | Recombinant Mouse STAMBP Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
STAMBP-1427HCL | Recombinant Human STAMBP 293 Cell Lysate | +Inquiry |
STAMBP-1428HCL | Recombinant Human STAMBP 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (0)
Ask a questionAsk a Question for All STAMBP Products
Required fields are marked with *
My Review for All STAMBP Products
Required fields are marked with *
0
Inquiry Basket