Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at BIO-Europe Spring|March 18–20, 2024|Booth #34

Active Recombinant Human STAMBP, GST-tagged

Cat.No. : STAMBP-167H
Product Overview : Recombinant human STAMBP (amino acid residues 252-424), fused with N-terminal GST, was expressed in E.coli.
  • Specification
  • Gene Information
  • Related Products
Description : AMSH is a member of the JAB1/MPN/Mov34 metalloenzyme (JAMM) family and cloning of the human gene was first described by Tanaka et al. (1999). AMSH and AMSH-LP share 54% identity and 75% sequence similarity in their JAMM domain. It is known that both proteins act as regulators of free ubiquitin in the cell, bind clathrin, and contain a putative nuclear localization signal and a microtubule interacting and transport (MIT) domain. AMSH also contains a Src homology 3 (SH3) domain, facilitating its interaction with signal transducing adaptor molecule (STAM), while this functional SH3-binding motif is lost in AMSH-LP (Davies, et al., 2011).
Source : E. coli
Species : Human
Tag : GST
Form : 50 mM HEPES pH 7.5, 150 mM sodium chloride, 2 mM dithiothreitol, 10% glycerol
Bio-activity : The activity of GST-AMSH CD(252-424) was validated by the monitoring of mono-ubiquitin generation as a result of the enzyme catalysed cleavage of K63-linked di-ubiquitin. Incubation of the substrate in the presence or absence of GST-AMSH CD(252-424) was compared confirming the deubiquitylating activity of GST-AMSH CD(252-424).
Molecular Mass : 47.1 kDa
Purity : >89% by SDS-PAGE
Storage : 12 months at -70°C. Avoid multiple freeze/thaw cycles.
Concentration : 0.5 mg/ml
Gene Name : STAMBP STAM binding protein [ Homo sapiens ]
Official Symbol : STAMBP
Synonyms : STAMBP; STAM binding protein; STAM-binding protein; AMSH; endosome-associated ubiquitin isopeptidase; associated molecule with the SH3 domain of STAM; MGC126516; MGC126518;
Gene ID : 10617
mRNA Refseq : NM_006463
Protein Refseq : NP_006454
MIM : 606247
UniProt ID : O95630
Chromosome Location : 2p24.3-p24.1
Pathway : Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Internalization of ErbB1, organism-specific biosystem;
Function : metal ion binding; metallopeptidase activity; peptidase activity; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All STAMBP Products

Required fields are marked with *

My Review for All STAMBP Products

Required fields are marked with *

0

Inquiry Basket

cartIcon
logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends