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Recombinant Chicken AREGB

Cat.No. : AREGB-3181C
Product Overview : Recombinant Chicken AREGB full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Chicken
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 oC for short term. For long term storage, store it at -20 oC~-80 oC.
Storage Buffer : PBS buffer
Gene Name : AREGB amphiregulin B [ Gallus gallus (chicken) ]
Official Symbol : AREGB
Gene ID : 428752
Protein Refseq : NP_001026708
UniProt ID : Q645M5

Related Gene

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (24)

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Are there any known inhibitors or activators of the AREGB protein? 04/21/2023

Currently, there are no specific inhibitors or activators of the AREGB protein that have been widely studied or developed for therapeutic use. However, targeting upstream regulators or downstream signaling pathways of AREGB, such as EGFR inhibitors or MAPK pathway inhibitors, may indirectly modulate the activity of AREGB. Further research is needed to identify specific modulators of AREGB and their potential therapeutic applications.

Are there any genetic mutations associated with the AREGB protein? 12/04/2021

Yes, certain genetic mutations in the AREGB gene have been reported. These mutations can disrupt its normal function and have been linked to diseases such as asthma and inflammatory bowel disease.

Can the AREGB protein interact with other signaling pathways? 10/03/2021

Yes, the AREGB protein can interact with other signaling pathways. It can crosstalk with various growth factor receptors, including the epidermal growth factor receptor (EGFR) pathway, and activate downstream signaling cascades involved in cell proliferation, migration, and survival.

Are there any ongoing clinical trials targeting the AREGB protein? 05/29/2021

Currently, there are no specific clinical trials targeting the AREGB protein. However, clinical trials evaluating treatments that target the EGFR pathway, which includes AREGB signaling, are being conducted for cancer and other diseases.

Can the AREGB protein modulate immune responses? 03/02/2021

Yes, the AREGB protein can modulate immune responses. It can act as a chemoattractant for immune cells, such as macrophages, neutrophils, and T cells, and promote their recruitment to sites of inflammation. Additionally, it can regulate cytokine production and immune cell function.

How is the expression of the AREGB protein regulated during development? 11/25/2020

The expression of the AREGB protein is tightly regulated during development. It is influenced by various factors, including growth factors, morphogens, and transcription factors that coordinate its expression in specific tissues and at specific stages of development.

Can the AREGB protein interact with cell surface receptors? 08/31/2020

Yes, the AREGB protein can interact with cell surface receptors. One of its known interaction partners is the epidermal growth factor receptor (EGFR). AREGB can bind to EGFR and activate downstream signaling cascades. Other potential interaction partners for AREGB include other growth factor receptors or transmembrane proteins involved in cell signaling processes.

Is the AREGB protein implicated in angiogenesis? 03/03/2020

Yes, the AREGB protein is implicated in angiogenesis, the process of forming new blood vessels. It can promote endothelial cell migration and proliferation, which are crucial steps in angiogenesis. Therefore, targeting AREGB signaling may have implications in therapeutic approaches aimed at inhibiting or promoting angiogenesis in different contexts.

What receptors does the AREGB protein bind to? 12/15/2019

The AREGB protein binds to the epidermal growth factor receptor (EGFR) and erb-b2 receptor tyrosine kinase 4 (ERBB4) receptors, activating downstream signaling pathways.

Is the expression of the AREGB protein regulated by transcription factors? 08/30/2019

Yes, the expression of the AREGB protein can be regulated by transcription factors. For example, the transcription factor AP-1 has been shown to bind to the promoter region of the AREGB gene and regulate its expression. Other transcription factors and signaling pathways may also play a role in modulating the expression of AREGB in different cellular contexts.

Does the AREGB protein have any prognostic or diagnostic value in cancer? 12/16/2018

Yes, the expression level of the AREGB protein has been investigated as a prognostic and diagnostic marker in various types of cancer. Its elevated expression is associated with poor prognosis and can potentially serve as a biomarker for disease progression.

Can the AREGB protein promote cancer progression? 07/19/2018

Yes, in certain cases, the overexpression of the AREGB protein has been associated with cancer progression, as it can promote cell proliferation, migration, invasion, and angiogenesis.

Is the AREGB protein a potential therapeutic target? 05/12/2018

Yes, due to its involvement in various diseases, the AREGB protein has been identified as a potential therapeutic target. Targeting its signaling pathways or inhibiting its expression could have therapeutic benefits in certain diseases.

What are the potential therapeutic applications of targeting the AREGB protein? 04/09/2018

Targeting the AREGB protein has potential therapeutic applications in various fields. It could be targeted for wound healing therapies, where promoting its expression or activity may enhance the healing process. Additionally, modulating the expression or activity of AREGB could have implications in immune-related diseases, tissue regeneration, and cancer treatment.

Can the AREGB protein be used as a biomarker for specific diseases? 03/16/2018

The AREGB protein has been investigated as a potential biomarker for certain diseases. For example, its overexpression has been associated with increased severity of chronic obstructive pulmonary disease (COPD). However, more research is needed to evaluate its diagnostic and prognostic value across different diseases.

Is the expression of the AREGB protein tissue-specific? 12/22/2017

The expression of the AREGB protein is not solely tissue-specific. It has been detected in various tissues and cell types, including the lungs, skin, gastrointestinal tract, and reproductive organs. However, the level of expression may vary across different tissues and can be influenced by various factors such as developmental stage, disease state, and cellular context.

Can the dysregulation of the AREGB protein contribute to tissue damage and disease? 11/19/2017

Yes, the dysregulation of the AREGB protein can contribute to tissue damage and disease. For example, its overexpression can lead to chronic inflammation, tissue remodeling, and fibrosis, whereas its underexpression or loss of function can impair wound healing and tissue repair processes.

How is the AREGB protein involved in wound healing? 08/26/2017

The AREGB protein is released in response to tissue injury and plays a crucial role in promoting wound healing. It stimulates cell migration, proliferation, and the production of extracellular matrix components, which aid in the repair and closure of the wound.

Are there any diseases or conditions associated with the dysregulation of the AREGB protein? 07/01/2017

Yes, the dysregulation of the AREGB protein has been linked to various diseases and conditions, including inflammatory bowel disease, asthma, chronic obstructive pulmonary disease (COPD), and certain types of cancer.

Are there any drugs or therapies targeting the AREGB protein currently available? 06/12/2017

As of now, there are no specific drugs or therapies specifically targeting the AREGB protein. However, ongoing research in this field may lead to the development of targeted therapies in the future.

What are the downstream signaling pathways activated by the AREGB protein? 04/19/2017

The AREGB protein can activate several downstream signaling pathways. One of the main pathways activated by AREGB is the mitogen-activated protein kinase (MAPK) pathway, which includes extracellular signal-regulated kinase (ERK) and p38 MAPK. Activation of this pathway by AREGB can promote cell proliferation, migration, and survival. Additionally, AREGB can activate the phosphatidylinositol-3 kinase (PI3K)/Akt pathway, which is involved in cell survival and growth. The precise signaling pathways activated by AREGB may vary depending on the cell type and context.

Are there any known mutations or genetic variations in the AREGB gene? 07/19/2016

Currently, there is limited information available on mutations or genetic variations specifically in the AREGB gene. However, genetic variations in genes encoding proteins involved in the same signaling pathways as AREGB, such as EGFR, have been linked to various diseases including cancer. It is possible that further research could uncover genetic variations or mutations in the AREGB gene that are associated with specific diseases or traits.

Is the AREGB protein involved in development and differentiation? 06/17/2016

Yes, the AREGB protein is involved in development and differentiation processes. It plays a role in embryonic development and has been implicated in the differentiation of various cell types, including epithelial, endothelial, and neuronal cells.

Is the AREGB protein implicated in neurological disorders? 03/08/2016

There is limited evidence suggesting that the AREGB protein may be implicated in neurological disorders. It has been shown to play a role in neuronal differentiation during development. However, further research is needed to explore its potential involvement in neurological diseases and disorders.

Customer Reviews (8)

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Reviews
07/28/2020

    The AREGB protein has proven to be an invaluable tool in my experimental trials.

    10/16/2019

      the AREGB protein is carefully characterized, and its functional properties are well-documented.

      05/02/2019

        Whether studying its role in cell adhesion, signal transduction, or host-pathogen interactions, the AREGB protein consistently delivers reliable and reproducible results.

        01/23/2018

          The knowledgeable and responsive support team is dedicated to resolving issues and providing solutions that are tailored to specific experimental requirements.

          05/09/2017

            They have not only provided insightful guidance on experimental design but also helped troubleshoot any issues I encountered during the trials.

            03/30/2017

              The AREGB protein is of exceptional quality and is perfectly suited to meet the experimental needs of researchers.

              03/25/2017

                This enables researchers to confidently incorporate AREGB into their studies, knowing that they have access to a reliable and well-characterized protein that will contribute to robust and accurate results.

                04/07/2016

                  As a researcher utilizing the AREGB protein in my trials, I am thrilled to highlight the numerous advantages it offers and how the manufacturer's support enhances my work.

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