Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Chicken ADORA1

Cat.No. : ADORA1-5889C
Product Overview : Recombinant Chicken ADORA1 full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Chicken
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 oC for short term. For long term storage, store it at -20 oC~-80 oC.
Storage Buffer : PBS buffer
Gene Name : ADORA1 adenosine A1 receptor [ Gallus gallus (chicken) ]
Official Symbol : ADORA1
Gene ID : 374212
Protein Refseq : NP_989647
UniProt ID : P49892

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (12)

Ask a question
What techniques are used to study ADORA1 proteins? 06/06/2022

A variety of techniques are used to study ADORA1 proteins, including molecular biology, biochemistry, and pharmacology. Molecular biology techniques can be used to clone and express ADORA1 receptors for further study. Biochemical assays can be used to measure ADORA1 activity, such as cAMP production or intracellular calcium signaling. Pharmacological assays can be used to test the efficacy of drugs that target ADORA1, both in vitro and in vivo.

Are there any diseases that result from mutations in the ADORA1 gene? 03/23/2021

While mutations in the ADORA1 gene have not been specifically implicated in diseases, variations in ADORA1 gene expression and activity have been associated with various pathological conditions. For example, increased ADORA1 expression has been correlated with the development of lung cancer and glioma, while decreased ADORA1 expression has been associated with rheumatoid arthritis and ischemic heart disease.

How is ADORA1 involved in sleep regulation? 10/26/2020

ADORA1 is involved in sleep regulation by promoting sleep and reducing wakefulness. Specifically, ADORA1 activation promotes slow wave sleep (SWS), which is a deep stage of non-REM sleep characterized by low cortical activity and is thought to be restorative. This effect is likely mediated by ADORA1 activation on neurons in the brain that promote SWS. In addition, caffeine, a non-selective adenosine receptor antagonist, blocks ADORA1 activation and reduces the propensity for SWS, resulting in increased wakefulness.

Can ADORA1 be used as a therapeutic target? 11/30/2019

Yes, ADORA1 is an attractive therapeutic target for several medical conditions. For example, drugs that selectively activate or inhibit ADORA1 could be used to treat inflammatory diseases by modulating immune cell activation and inflammatory signaling. Additionally, targeting ADORA1 could be a useful approach for treating cancers that overexpress this receptor, as inhibiting ADORA1 activation could potentially slow tumor growth and metastasis.

Are there any genetic mutations associated with ADORA1 that affect health? 11/30/2019

Yes, there are genetic mutations associated with ADORA1 that can affect health. One such mutation is a single nucleotide polymorphism (SNP) in the ADORA1 gene that has been linked to increased susceptibility to autoimmune and inflammatory diseases such as rheumatoid arthritis and psoriasis. Another SNP has been found to be associated with a higher risk of developing Alzheimer's disease. These findings suggest that genetic variations in ADORA1 may impact immune function and neurodegenerative diseases.

How does ADORA1 interact with other neurotransmitter systems in the brain? 08/06/2019

ADORA1 interacts with other neurotransmitter systems in the brain by modulating their activity. For example, ADORA1 activation can inhibit the release of glutamate, a major excitatory neurotransmitter, and increase the release of GABA, a major inhibitory neurotransmitter. ADORA1 activation can also modulate the activity of dopamine, serotonin, and acetylcholine neurotransmitter systems, among others. These interactions suggest that ADORA1 plays a role in the complex network of neurotransmitter systems that regulate brain function and behavior.

Can ADORA1 proteins be used as biomarkers for disease? 12/11/2017

ADORA1 proteins may have potential as biomarkers for certain disease conditions. For example, ADORA1 expression has been shown to be upregulated in various cancer types, and ADORA1 has been proposed as a potential biomarker for breast cancer prognosis. Additionally, ADORA1 expression has been found to be altered in individuals with major depressive disorder, suggesting that it may have potential as a diagnostic or prognostic biomarker for this condition.

What drugs target ADORA1 proteins? 07/12/2017

There are several drugs that target ADORA1 proteins. One example is caffeine, which is an adenosine receptor antagonist that binds to and blocks ADORA1 activation. Other drugs that target ADORA1 include the anti-inflammatory agent ibudilast, which has been shown to reduce ADORA1 expression and modulate inflammation in the central nervous system, and the bronchodilator theophylline, which is used to treat asthma and COPD by inhibiting ADORA1 activation.

What medical conditions are associated with ADORA1 dysfunction? 05/10/2017

Dysregulation of ADORA1 signaling has been implicated in a number of pathological conditions. For example, ADORA1 overexpression has been associated with tumor growth and metastasis in certain cancers. In the brain, ADORA1 activation has been linked to the development of epileptic seizures and neuronal degeneration in Huntington's disease. Conversely, ADORA1 deficiency has been associated with insulin resistance and the development of type 2 diabetes.

Can ADORA1 be targeted for pain relief? 02/06/2017

Yes, ADORA1 has been identified as a potential target for pain relief. Activation of ADORA1 produces anti-nociceptive effects, meaning it can alleviate pain. Several studies have looked at selective ADORA1 agonists for their potential as analgesics. In addition, caffeine has been shown to have an indirect effect on ADORA1, leading to pain relief in certain conditions.

What research is currently being conducted on ADORA1? 05/27/2016

Research on ADORA1 is ongoing in a number of areas, including cancer biology, neuroscience, and immunology. One current area of investigation is the role of ADORA1 in chronic pain, as it has been shown to be upregulated in certain pain conditions. Additionally, ADORA1 is being studied as a potential target for Parkinson's disease, as ADORA1 agonists have been shown to improve motor symptoms in animal models of the disease.

Are there any side effects associated with targeting ADORA1 in drug development? 02/25/2016

Yes, there can be side effects associated with targeting ADORA1. For example, drugs that activate or block ADORA1 may affect cardiovascular function, including heart rate and blood pressure. Other potential side effects include altered immune system function, sedation, and gastrointestinal effects. As with any drug development, careful evaluation of safety and efficacy must be conducted to determine the potential benefits and drawbacks of targeting ADORA1.

Customer Reviews (4)

Write a review
Reviews
12/08/2020

    the purity and activity of the protein are impressive and give me confidence in obtaining reproducible and meaningful results.

    12/09/2019

      The extensive technical support provided by the manufacturer has already addressed some of my concerns and I am confident that they will be able to assist me further should I require more information or help.

      11/04/2019

        I am satisfied with the product and the service, and I would recommend it to other researchers who may need a reliable ADORA1 protein source.

        07/03/2017

          Based on its characteristics and qualities, I am confident that the ADORA1 protein will perfectly suit my experimental requirements.

          Ask a Question for All ADORA1 Products

          Required fields are marked with *

          My Review for All ADORA1 Products

          Required fields are marked with *

          0

          Inquiry Basket

          cartIcon
          logo

          FOLLOW US

          Terms and Conditions        Privacy Policy

          Copyright © 2024 Creative BioMart. All Rights Reserved.

          Contact Us

          • /

          Stay Updated on the Latest Bioscience Trends