Cat. No.:	CRADD-384H
Product Overview:	Recombinant CRADD protein was expressed in E.coli and purified by using conventional chromatography techniques,24.9kDa (219aa).
Description:	CRADD is a 22 kDa, widely-expressed cytosolic adaptor protein. CRADD is a death domain (CARD/DD) containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins.
Sequences of amino acids:	MGSSHHHHHH SSGLVPRGSH MEARDKQVLR SLRLELGAEV LVEGLVLQYL YQEGILTENH IQEINAQTTG LRKTMLMLDI LPSRGPKAFD TFLDSLQEFP WVREKLKKAR EEAMTDLPAG DRLTGIPSHI LNSSPSDRQI NQLAQRLGPE WEPMVLSLGL SQTDIYRCKA NHPHNVQSQV VEAFIRWRQR FGKQATFQSL HNGLRAVEVD PSLLLHMLE
Formulation:	Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol
Purity:	> 95% by SDS - PAGE
Concentration:	1 mg/ml (determined by Bradford assay)
Storage:	Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Name:	CRADD CASP2 and RIPK1 domain containing adaptor with death domain [ Homo sapiens ]
Synonyms:	CRADD; CASP2 and RIPK1 domain containing adaptor with death domain; RAIDD; MGC9163; death adaptor molecule RAIDD; death domain containing protein CRADD; caspase and RIP adaptor with death domain; RIP-associated protein with a death domain; RIP-associated ICH1/CED3-homologous protein with death domain
Gene ID:	8738
mRNA Refseq:	NM_003805
Protein Refseq:	NP_003796
MIM:	603454
UniProt ID:	P78560
Chromosome Location:	12q21.33-q23.1
Function:	cysteine-type endopeptidase activity; death domain binding; protease binding; protein binding, bridging

Online Inquiry