Recombinant Human CASP2 and RIPK1 Domain Containing Adaptor With Death Domain, His-tagged

• Cat.No.: CRADD-384H
• Product Overview: Recombinant CRADD protein was expressed in E.coli and purified by using conventional chromatography techniques,24.9kDa (219aa).

Specification

• Cat. No.: CRADD-384H
• Description: CRADD is a 22 kDa, widely-expressed cytosolic adaptor protein. CRADD is a death domain (CARD/DD) containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MEARDKQVLR SLRLELGAEV LVEGLVLQYL YQEGILTENH IQEINAQTTG LRKTMLMLDI LPSRGPKAFD TFLDSLQEFP WVREKLKKAR EEAMTDLPAG DRLTGIPSHI LNSSPSDRQI NQLAQRLGPE WEPMVLSLGL SQTDIYRCKA NHPHNVQSQV VEAFIRWRQR FGKQATFQSL HNGLRAVEVD PSLLLHMLE
• Formulation: Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol
• Purity: > 95% by SDS - PAGE
• Concentration: 1 mg/ml (determined by Bradford assay)
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: CRADD CASP2 and RIPK1 domain containing adaptor with death domain [ Homo sapiens ]
• Synonyms: CRADD; CASP2 and RIPK1 domain containing adaptor with death domain; RAIDD; MGC9163; death adaptor molecule RAIDD; death domain containing protein CRADD; caspase and RIP adaptor with death domain; RIP-associated protein with a death domain; RIP-associated ICH1/CED3-homologous protein with death domain
• Gene ID: 8738
• mRNA Refseq: NM_003805
• Protein Refseq: NP_003796
• MIM: 603454
• UniProt ID: P78560
• Chromosome Location: 12q21.33-q23.1
• Function: cysteine-type endopeptidase activity; death domain binding; protease binding; protein binding, bridging