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Recombinant Zebrafish ARF3A

Cat.No. : ARF3A-891Z
Product Overview : Recombinant Zebrafish ARF3A full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Zebrafish
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 oC for short term. For long term storage, store it at -20 oC~-80 oC.
Storage Buffer : PBS buffer
Gene Name : arf3a ADP-ribosylation factor 3a [ Danio rerio (zebrafish) ]
Official Symbol : ARF3A
Gene ID : 445047
mRNA Refseq : NM_001003441
Protein Refseq : NP_001003441
UniProt ID : Q6DHP3

Related Gene

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (19)

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Can the ARF3A protein be regulated by post-translational modifications other than myristoylation? 02/25/2023

Yes, the ARF3A protein can be regulated by other post-translational modifications. For example, it can be phosphorylated by protein kinases, which can modulate its activity and interaction with downstream effectors. Additionally, ARF3A can undergo ubiquitination, which can affect its stability and turnover.

Can alterations in ARF3A expression or function lead to disease? 03/05/2022

While specific disease associations with ARF3A are limited, dysregulation of ARF proteins in general has been implicated in diseases such as cancer, Alzheimer's disease, and various genetic disorders that affect vesicular trafficking and membrane dynamics.

Are there any pharmacological agents or compounds that can modulate the activity of ARF3A? 01/24/2022

Currently, there are no known specific pharmacological agents or compounds that selectively modulate the activity of ARF3A. However, certain compounds that target general processes in vesicular trafficking, such as inhibitors of GTPase activity, COPI or clathrin function, may indirectly affect ARF3A-mediated processes. Development of selective modulators targeted specifically at ARF3A may be an area of future research.

Can you explain the structural characteristics of the ARF3A protein? 09/21/2021

The ARF3A protein consists of a core domain composed of six alpha-helices and six beta-strands. It also possesses N-terminal myristoylation and interswitch regions that play a crucial role in its function.

Can you explain the myristoylation of the ARF3A protein? 07/26/2021

Myristoylation is a post-translational modification in which a myristic acid molecule is covalently attached to the N-terminal glycine residue of the ARF3A protein. This modification is important for the proper membrane association and functioning of the protein.

What are the binding partners of the ARF3A protein? 06/25/2021

The ARF3A protein interacts with various effector proteins, such as coat proteins involved in vesicle formation and other regulatory factors involved in intracellular trafficking.

Are there any known interacting proteins or complexes associated with the ARF3A protein? 08/01/2020

Yes, the ARF3A protein interacts with various effectors and regulatory proteins. Some examples include the COPI and clathrin coat proteins, ARF GEFs (guanine nucleotide exchange factors), ARF GAPs (GTPase-activating proteins), and proteins involved in vesicle docking and fusion.

Are there any research areas currently focused on studying the ARF3A protein? 06/15/2020

Ongoing research on the ARF3A protein includes investigations into its precise role in specific cellular processes, identification of new interacting partners, and understanding its involvement in disease states. Additionally, studies may explore potential therapeutic targets related to the ARF3A protein.

Does the ARF3A protein play a role in neuronal cells? 06/15/2020

While the specific role of ARF3A in neuronal cells is not extensively studied, ARF proteins as a whole have been implicated in various cellular processes in neurons. These include synaptic vesicle trafficking, dendritic spine morphology, and neuronal polarization. Therefore, it is possible that ARF3A might contribute to these neuronal processes, but more research is needed to elucidate its specific functions in neurons.

How are ARF proteins involved in membrane remodeling? 05/09/2020

ARF3A and other ARF family proteins regulate membrane remodeling by promoting the recruitment of coat proteins and other effectors to specific membrane compartments. This leads to changes in membrane curvature and vesicle budding.

How is the ARF3A protein involved in vesicular trafficking? 04/18/2020

The ARF3A protein acts as a molecular switch by binding to GTP (guanosine triphosphate) or GDP (guanosine diphosphate), and this GTPase activity regulates the recruitment and release of coat proteins during vesicle formation and intracellular trafficking.

How does the ARF3A protein contribute to cellular signal transduction? 02/16/2020

The ARF3A protein can act as a signaling molecule by influencing downstream effector proteins, such as protein kinases and phospholipases, which in turn affect cellular processes and response to external stimuli.

Are there any known genetic mutations associated with the ARF3A protein? 10/26/2019

Currently, there are no known disease-causing mutations specifically associated with the ARF3A protein. However, dysregulation of ARF proteins in general has been implicated in various pathological conditions, including cancer and neurodegenerative diseases.

Can the ARF3A protein interact with lipid molecules? 10/06/2018

Yes, the ARF3A protein can interact with lipid molecules. Its myristoylation allows it to associate with membranes, and some studies have shown that ARF proteins preferentially bind to certain phospholipids, such as phosphatidylinositol 4,5-bisphosphate (PIP2). These lipid interactions can play a role in recruiting ARF3A to specific membrane compartments.

What cellular processes are impacted by the ARF3A protein? 08/25/2018

The ARF3A protein regulates processes such as endocytosis, exocytosis, Golgi apparatus integrity, membrane recycling, and the formation of transport vesicles.

Does the ARF3A protein have any isoforms or alternate splice variants? 01/30/2018

The ARF3A protein does not have any widely reported isoforms or splice variants. However, it is always important to consider that new discoveries can be made as research progresses.

Is the ARF3A protein conserved across different species? 10/22/2017

Yes, the ARF3A protein is conserved across different species. It is found in various organisms ranging from yeast to mammals, indicating its importance and functional relevance in cellular processes.

Is the expression of the ARF3A gene regulated in a tissue-specific manner? 05/06/2017

The tissue-specific regulation of the ARF3A gene has not been extensively studied. However, ARF proteins, including ARF3A, are known to exhibit distinct expression patterns in different tissues and cell types. This suggests that there may be some level of tissue-specific regulation for ARF3A, but more research is needed to fully understand its expression regulation.

Are there any therapeutic implications related to the ARF3A protein? 07/19/2016

Since the ARF3A protein is involved in cellular processes that are dysregulated in various diseases, targeting its activity or its interacting partners could have therapeutic implications in conditions related to membrane trafficking and organelle dynamics. However, specific drug targeting for ARF3A has not been extensively explored yet.

Customer Reviews (8)

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Reviews
12/18/2022

    The outstanding level of customer service adds extra reassurance and confidence in using the ARF3A protein for my scientific investigations.

    12/31/2021

      the manufacturer of ARF3A provides exceptional technical support, offering valuable assistance in troubleshooting and experimental design.

      12/07/2021

        the ARF3A protein has proven to be an invaluable tool in protein electron microscopy (EM) structure analysis.

        09/13/2021

          This protein demonstrates great performance in WB assays, providing accurate and reliable results that are crucial for protein analysis.

          06/09/2020

            The ARF3A protein surpasses expectations in terms of quality and will undoubtedly fulfill my experimental requirements.

            04/22/2019

              Its high quality greatly enhances the reliability and reproducibility of experimental data.

              05/08/2017

                ts reliability and high quality make it a valuable tool in various applications, ranging from enzymatic assays to studying protein-protein interactions.

                01/07/2016

                  The ARF3A protein is highly recommended for researchers conducting protein studies, especially in Western blotting (WB) experiments.

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