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Recombinant Human Fumarate Hydratase

Cat. No.: FH -112H
Product Overview: Recombinant Fumarase was expressed in E.coli and was purified by conventional chromatography techniques, 50.2kDa (467aa).
Description: Fumarase (Fumarate hytdratase) is an enzyme that catalyzes the reversible hydration/dehydration of fumarate to S-malate and is involved in the tricarboxylic acid (TCA), or Krebs cycle. This enzyme exists in both a cytosolic form and an N-terminal extended mitochondrial form. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension is the same form as in the cytoplasm. Fumarase deficiency can lead to progressive encephalopathy, cerebral atrophy and developmental delay and this enzyme also is thought to act as a tumor suppressor.
Source: Escherichia Coli.
Form: Liquid. In 20 mM Tris-HCl buffer (pH 8.0)
Purity: > 95% by SDS - PAGE.
Concentration: 1 mg/ml (determined by Bradford assay)
Endotoxin Level: < 1.0 EU per 1 μg of protein (determined by LAL method)
Sequences of amino acids: MASQNSFRIE YDTFGELKVP NDKYYGAQTV RSTMNFKIGG VTERMPTPVI KAFGILKRAA AEVNQDYGLD PKIANAIMKA ADEVAEGKLNDHF PLVV WQT GSGTQTNMNV NEVISNRAIE MLGGELGSKI PVHPNDHVNK SQSSNDTFPT AMHIAAAIEV HEVLLPGLQK LHDALDAKSK EFAQIIKIGR THTQD AVPLT LGQEFSGYVQ QVKYAMTRIK AAMPRIYELA AGGTAVGTGL NTRIGFAEKV AAKVAALTGL PFVTAPNKFE ALAAHDALVE LSGAMNTTAC SLM KIA NDIRFLGSGPRSGLGELILPENEP GSSIMPGKVN PTQCEAMTMV AAQVMGNHVA VTVGGSNGHF ELNVFKPMMI KNVLHSARLL GDASVSFTEN CVVGIQANTE RINKLMNESL MLVTALNPHI GYDKAAKIAK TAHKNGSTLK ETAIELGYLT AEQFDEWVKP KDMLGPK
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: FH fumarate hydratase [ Homo sapiens ]
Synonyms: MCL; LRCC; HLRCC; MCUL1; FH; fumarate hydratase; fumarase; OTTHUMP00000037573; EC 4.2.1.2; Fumarase.
Gene ID: 2271
mRNA Refseq: NM_000143
Protein Refseq: NP_000134
MIM: 136850
UniProt ID: P07954
Chromosome Location: 1q42.1
Function: fumarate hydratase activity, fumarate hydratase activity, lyase activity

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