Recombinant Human Geminin, DNA Replication Inhibitor, His-tagged

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Recombinant Human Geminin, DNA Replication Inhibitor, His-tagged

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Cat. No. : GMNN-353H
Product Overview : Recombinant human GMNN protein expressed in E.coli, 27.6kDa (245aa).
Description : Recombinant human, Geminin is a 25 kDa protein, which inhibits DNA replication and is degraded during the mitotic phase of the cell cycle. Geminin controls replication by binding to the licensing factor Cdt1, and is involved in neural differentiation. In addition, geminin directly interacts with Six3 and Hox homeodomain proteins during embryogenesis and inhibits their functions.
Source : Escherichia Coli.
Form : Liquid. In 20 mM Tris-HCl buffer (pH 7.5) containing 100 mM NaCl, 5 mM DTT, 20% glycerol.
Purity : > 95% by SDS - PAGE.
Concentration : 1 mg/ml (determined by Bradford assay)
Sequences of amino acids : MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMNPS MKQK QE EIK E NIKNSSVPRR TLKMIQPSAS GSLVGRENEL SAGLSKRKHR NDHLTS T TSS PGVIVPESSE NKNLGGVTQE SFDLMIKENP SSQYWKEVAE KRRKALY EAL KENEKLHKEI EQKDNEIARL KKENKELAEV AEHVQYMAEL IERLNGEP LD NFESLDNQEF DSEEETVEDS LVEDSEIGTC AEGTVSSSTD AKPCI
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
PDB rendering based on 1t6f. Available structures: 1t6f, 1uii :

Gene Name : GMNN geminin, DNA replication inhibitor [ Homo sapiens ]
Synonyms : GMNN; Gem; RP3-369A17.3; geminin; OTTHUMP00000039393; geminin, DNA replication inhibitor.
Gene ID : 51053
mRNA Refseq : NM_015895
Protein Refseq : NP_056979
MIM : 602842
UniProt ID : O75496
Chromosome Location : 6p22.3
Function : protein binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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