Recombinant Zebrafish ARSK
Cat.No. : | ARSK-4616Z |
Product Overview : | Recombinant Zebrafish ARSK full length or partial length protein was expressed. |
- Specification
- Gene Information
- Related Products
Source : | Mammalian Cells |
Species : | Zebrafish |
Tag : | His |
Form : | Liquid or lyophilized powder |
Endotoxin : | < 1.0 eu per μg of the protein as determined by the LAL method. |
Purity : | >80% |
Notes : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Storage : | Store it at +4 oC for short term. For long term storage, store it at -20 oC~-80 oC. |
Storage Buffer : | PBS buffer |
Gene Name : | arsk arylsulfatase family, member K [ Danio rerio (zebrafish) ] |
Official Symbol : | ARSK |
Gene ID : | 562412 |
mRNA Refseq : | NM_001077157 |
Protein Refseq : | NP_001070625 |
UniProt ID : | Q08CJ7 |
Products Types
◆ Recombinant Protein | ||
ARSK-761M | Recombinant Mouse ARSK Protein, His (Fc)-Avi-tagged | +Inquiry |
ARSK-464R | Recombinant Rat ARSK Protein, His (Fc)-Avi-tagged | +Inquiry |
ARSK-868H | Recombinant Human ARSK protein, GST-tagged | +Inquiry |
ARSK-808R | Recombinant Rat ARSK Protein | +Inquiry |
ARSK-3066C | Recombinant Chicken ARSK | +Inquiry |
◆ Lysates | ||
ARSK-8673HCL | Recombinant Human ARSK 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
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Q&As (10)
Ask a questionThe ARSK protein is known to hydrolyze a specific class of sulfates known as sulfatides. Sulfatides are a type of glycosphingolipid found in various tissues and cells, particularly in the nervous system. ARSK catalyzes the breakdown of sulfatides into sulfate ions and ceramide.
Yes, genetic variations or mutations in the ARSK gene have been reported in individuals with ARSK-related disorders. These variations can interfere with the proper functioning of the enzyme, leading to impaired sulfate metabolism and the associated clinical symptoms.
Deficiency or dysfunction of the ARSK protein can lead to a rare genetic disorder called ARSK-related disorder. This condition is characterized by the accumulation of sulfatides, a type of lipid, in various organs and tissues, leading to tissue damage and dysfunction.
Some studies have suggested that ARSK dysfunction and subsequent sulfatide accumulation may contribute to the pathogenesis of certain neurodegenerative diseases, such as multiple sclerosis and metachromatic leukodystrophy. The deposition of sulfatides in neural tissues may disrupt myelin integrity and impair nerve conduction.
Currently, there are no specific treatments or therapies available for ARSK-related disorders. Management typically involves symptomatic and supportive care to address the specific symptoms and complications that arise due to sulfatide accumulation.
Yes, genetic testing can be used to diagnose ARSK-related disorders. By sequencing the ARSK gene and identifying disease-causing variations or mutations, a definitive diagnosis can be made. Genetic counseling may also be offered to affected individuals and their families.
The long-term effects of ARSK dysfunction may vary depending on the severity and specific manifestations of the disorder. Sulfatide accumulation can lead to damage in various organs, including the brain, liver, and kidneys, resulting in neurological, hepatic, or renal impairments over time.
Currently, there is limited research on whether the ARSK protein is implicated in other diseases or conditions. Further studies are needed to determine if it plays a role in other aspects of sulfate metabolism or if dysregulation of ARSK is associated with other disorders.
At present, no specific inhibitors or activators of the ARSK protein have been identified. The development of small molecules or compounds that can modulate ARSK activity could hold potential for future therapeutic interventions, but more research is needed in this area.
The regulation of the ARSK protein is not fully understood. It is likely controlled at the transcriptional level, where the expression of the ARSK gene is influenced by various regulatory factors. Additionally, post-translational modifications and protein-protein interactions may also participate in the regulation of ARSK activity.
Customer Reviews (3)
Write a reviewWhen used in Western Blotting experiments, the ARSK protein consistently generates clear and distinct protein bands.
It has been invaluable in protein electron microscopy structure analysis, facilitating detailed investigations and yielding valuable insights.
This exceptional clarity allows for accurate quantification and analysis, contributing to the overall success of my research endeavors.
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