Recombinant Zebrafish ABHD16A
Cat.No. : | ABHD16A-6239Z |
Product Overview : | Recombinant Zebrafish ABHD16A full length or partial length protein was expressed. |
- Specification
- Gene Information
- Related Products
Source : | Mammalian Cells |
Species : | Zebrafish |
Tag : | His |
Form : | Liquid or lyophilized powder |
Endotoxin : | < 1.0 eu per μg of the protein as determined by the LAL method. |
Purity : | >80% |
Notes : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Storage : | Store it at +4 oC for short term. For long term storage, store it at -20 oC~-80 oC. |
Storage Buffer : | PBS buffer |
Gene Name : | abhd16a abhydrolase domain containing 16A [ Danio rerio (zebrafish) ] |
Official Symbol : | ABHD16A |
Gene ID : | 564613 |
mRNA Refseq : | NM_001111178 |
Protein Refseq : | NP_001104648 |
UniProt ID : | A9JR90 |
Products Types
◆ Recombinant Protein | ||
ABHD16A-13C | Recombinant Cynomolgus Monkey ABHD16A Protein, His (Fc)-Avi-tagged | +Inquiry |
ABHD16A-214M | Recombinant Mouse ABHD16A Protein, His (Fc)-Avi-tagged | +Inquiry |
ABHD16A-76R | Recombinant Rat ABHD16A Protein, His (Fc)-Avi-tagged | +Inquiry |
ABHD16A-1129M | Recombinant Mouse ABHD16A Protein | +Inquiry |
ABHD16A-090H | Recombinant Human ABHD16A protein, GST-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (10)
Ask a questionUsing STED microscopy, we can found that mammalian ABHD12 is enriched at the ER membrane30, then checked for the co-localization of ABHD16A with ABHD12. Indeed, we found in Neuro-2a cells, that ABHD16A co-localizes with ABHD12, further confirming that ABHD16A is enriched at the ER membrane.
A complicated hereditary spastic paraplegia (HSP) caused by ABHD16A loss of function pathogenic variants and the subsequent altered phosphatidylserine (PS) metabolism.
The protein deglycosylation studies and the detergent-independent sensitivity of ABHD16A to proteolytic degradation, have suggested this point.
Inhibited by beta-lactone-based lipid inhibitors, such as beta-lactone palmostatin-B
They are DTX2, RNF5, AGPAT3, TMEM147, and FAM134C.
ABHD16A is a 21-exon gene which encodes for the α/β hydrolase domain-containing 16A (ABHD16A) enzyme, which is the main brain phosphatidylserine (PS) hydrolase.
ABHD16A and ABHD12, are the main enzymes responsible for the brain LPS metabolism, as ABHD16A generates LPS while ABHD12 catabolizes them into fatty acid and phosphoserine.
ABHD16A PS lipase deficiency results in intellectual disability, progressive spasticity, abnormal corpus callosum, and white matter anomalies, most likely through the dysregulation of lipid species including lyso-PS.
We found relative to the tubulin protein loading control, that ABHD16A was maximally enriched in the cerebellum, and the olfactory bulb, while ABHD12 is ubiquitously expressed at near equal levels in all the aforementioned brain regions.
ABHD16A has a heterogeneous expression in the murine brain and is enriched in the cerebellum, particularly in the granular layer and the olfactory bulb.
Customer Reviews (3)
Write a reviewAlways good
5 stars for serivce for sure!
Suitable price, great!
Ask a Question for All ABHD16A Products
Required fields are marked with *
My Review for All ABHD16A Products
Required fields are marked with *
Inquiry Basket