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Recombinant Human P21 Protein-activated Kinase 4, His-tagged

Cat.No. : PAK4-105H
Product Overview : Recombinant PAK4 protein was expressed in E.coli and purified by using conventional chromatography techniques,68.3 kDa (628 aa).
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Cat. No. : PAK4-105H
Description : PAK4 is a member of the group B family of p21-activated kinases (PAK). It"s identified as an effector protein for cell division cycle 42(Cdc42) and protein that play an important role in regulating cytoskeletal organization and cell morphology. Its expression is elevated in many cancer cell lines, and suggested that it plays an important role in tumorigenesis.
Sequences of amino acids : MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMFG KRKKRVEISA PSNFEHRVHT GFDQHEQKFT GLPRQWQSLI EESARRPKPL VDPACITSIQ PGAPKTIVRG SKGAKDGALT LLLDEFENMS VTRSNSLRRD SPPPPARARQ ENGMPEEPAT TARGGPGKAG SRGRFAGHSE AGGGSGDRRR AGPEKRPKSS REGSGGPQES SRDKRPLSGP DVGTPQPAGL ASGAKLAAGR PFNTYPRADT DHPSRGAQGE PHDVAPNGPS AGGLAIPQSS SSSSRPPTRA RGAPSPGVLG PHASEPQLAP PACTPAAPAV PGPPGPRSPQ REPQRVSHEQ FRAALQLVVD PGDPRSYLDN FIKIGEGSTG IVCIATVRSS GKLVAVKKMD LRKQQRRELL FNEVVIMRDY QHENVVEMYN SYLVGDELWV VMEFLEGGAL TDIVTHTRMN EEQIAAVCLA VLQALSVLHA QGVIHRDIKS DSILLTHDGR VKLSDFGFCA QVSKEVPRRK SLVGTPYWMA PELISRLPYG PEVDIWSLGI MVIEMVDGEP PYFNEPPLKA MKMIRDNLPP RLKNLHKVSP SLKGFLDRLL VRDPAQRATA AELLKHPFLA KAGPPASIVP LMRQNRTR
Formulation : Liquid. In 50 mM Tris-HCl buffer (pH 8.0) containing 2 mM DTT
Purity : > 90% by SDS - PAGE
Concentration : 1 mg/ml (determined by Bradford assay)
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 [ Homo sapiens ]
Synonyms : PAK4; p21 protein (Cdc42/Rac)-activated kinase 4; p21-activated kinase 4;p21(CDKN1A)-activated kinase 4; protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs; Serine/threonine-protein kinase PAK 4; KIAA1142; EC 2.7.11.1; PAK-4
Gene ID : 10298
mRNA Refseq : NM_001014831
Protein Refseq : NP_001014831
MIM : 605451
UniProt ID : O96013
Chromosome Location : 19q13.2
Pathway : Axon guidance; ErbB signaling pathway; Focal adhesion; Regulation of actin cytoskeleton; Renal cell carcinoma; T cell receptor signaling pathway
Function : ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any FDA-approved drugs targeting PAK4? 12/19/2021

As of my knowledge cutoff date in January 2022, there were no FDA-approved drugs specifically targeting PAK4.

Are there any diagnostic tests based on PAK4 for cancer screening? 05/19/2021

PAK4 is not commonly used as a specific diagnostic marker for cancer screening. Other markers, like PSA for prostate cancer or mammography for breast cancer, are more common.

What are the current clinical trials involving PAK4 inhibitors? 06/26/2020

Clinical trials involving PAK4 inhibitors may vary over time. To find the latest information, you should consult clinical trial databases or healthcare professionals.

What are the challenges in developing PAK4 inhibitors for clinical use? 02/08/2020

Selectivity and potential side effects are challenges in developing PAK4 inhibitors, which need to be carefully addressed in clinical trials.

How is PAK4-related research contributing to personalized medicine? 05/14/2019

PAK4-related research may help identify specific patient populations that could benefit from PAK4-targeted therapies, contributing to personalized treatment approaches.

Customer Reviews (3)

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Reviews
11/16/2021

    The prompt and knowledgeable assistance they offer has greatly enhanced my confidence in using the PAK4 protein.

    03/01/2020

      I am highly satisfied with the performance and support associated with this protein, as it has proven to be an essential tool in advancing my scientific investigations.

      05/18/2016

        Its purity and reliability have provided consistent and reliable results in my research.

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