Recombinant Human P21 Protein-activated Kinase 4, His-tagged
Cat.No. : | PAK4-105H |
Product Overview : | Recombinant PAK4 protein was expressed in E.coli and purified by using conventional chromatography techniques,68.3 kDa (628 aa). |
- Specification
- Gene Information
- Related Products
Cat. No. : | PAK4-105H |
Description : | PAK4 is a member of the group B family of p21-activated kinases (PAK). It"s identified as an effector protein for cell division cycle 42(Cdc42) and protein that play an important role in regulating cytoskeletal organization and cell morphology. Its expression is elevated in many cancer cell lines, and suggested that it plays an important role in tumorigenesis. |
Sequences of amino acids : | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMFG KRKKRVEISA PSNFEHRVHT GFDQHEQKFT GLPRQWQSLI EESARRPKPL VDPACITSIQ PGAPKTIVRG SKGAKDGALT LLLDEFENMS VTRSNSLRRD SPPPPARARQ ENGMPEEPAT TARGGPGKAG SRGRFAGHSE AGGGSGDRRR AGPEKRPKSS REGSGGPQES SRDKRPLSGP DVGTPQPAGL ASGAKLAAGR PFNTYPRADT DHPSRGAQGE PHDVAPNGPS AGGLAIPQSS SSSSRPPTRA RGAPSPGVLG PHASEPQLAP PACTPAAPAV PGPPGPRSPQ REPQRVSHEQ FRAALQLVVD PGDPRSYLDN FIKIGEGSTG IVCIATVRSS GKLVAVKKMD LRKQQRRELL FNEVVIMRDY QHENVVEMYN SYLVGDELWV VMEFLEGGAL TDIVTHTRMN EEQIAAVCLA VLQALSVLHA QGVIHRDIKS DSILLTHDGR VKLSDFGFCA QVSKEVPRRK SLVGTPYWMA PELISRLPYG PEVDIWSLGI MVIEMVDGEP PYFNEPPLKA MKMIRDNLPP RLKNLHKVSP SLKGFLDRLL VRDPAQRATA AELLKHPFLA KAGPPASIVP LMRQNRTR |
Formulation : | Liquid. In 50 mM Tris-HCl buffer (pH 8.0) containing 2 mM DTT |
Purity : | > 90% by SDS - PAGE |
Concentration : | 1 mg/ml (determined by Bradford assay) |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Gene Name : | PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 [ Homo sapiens ] |
Synonyms : | PAK4; p21 protein (Cdc42/Rac)-activated kinase 4; p21-activated kinase 4;p21(CDKN1A)-activated kinase 4; protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs; Serine/threonine-protein kinase PAK 4; KIAA1142; EC 2.7.11.1; PAK-4 |
Gene ID : | 10298 |
mRNA Refseq : | NM_001014831 |
Protein Refseq : | NP_001014831 |
MIM : | 605451 |
UniProt ID : | O96013 |
Chromosome Location : | 19q13.2 |
Pathway : | Axon guidance; ErbB signaling pathway; Focal adhesion; Regulation of actin cytoskeleton; Renal cell carcinoma; T cell receptor signaling pathway |
Function : | ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity |
Products Types
◆ Recombinant Protein | ||
PAK4-1603H | Recombinant Human PAK4 Protein, His (Fc)-Avi-tagged | +Inquiry |
PAK4-766H | Recombinant Human PAK4 Protein, His-tagged | +Inquiry |
PAK4-319H | Recombinant Human PAK4 Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
Pak4-1894M | Recombinant Mouse Pak4 Protein, His-tagged | +Inquiry |
Pak4-4663M | Recombinant Mouse Pak4 Protein, Myc/DDK-tagged | +Inquiry |
◆ Lysates | ||
PAK4-3456HCL | Recombinant Human PAK4 293 Cell Lysate | +Inquiry |
PAK4-3455HCL | Recombinant Human PAK4 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionAs of my knowledge cutoff date in January 2022, there were no FDA-approved drugs specifically targeting PAK4.
PAK4 is not commonly used as a specific diagnostic marker for cancer screening. Other markers, like PSA for prostate cancer or mammography for breast cancer, are more common.
Clinical trials involving PAK4 inhibitors may vary over time. To find the latest information, you should consult clinical trial databases or healthcare professionals.
Selectivity and potential side effects are challenges in developing PAK4 inhibitors, which need to be carefully addressed in clinical trials.
PAK4-related research may help identify specific patient populations that could benefit from PAK4-targeted therapies, contributing to personalized treatment approaches.
Customer Reviews (3)
Write a reviewThe prompt and knowledgeable assistance they offer has greatly enhanced my confidence in using the PAK4 protein.
I am highly satisfied with the performance and support associated with this protein, as it has proven to be an essential tool in advancing my scientific investigations.
Its purity and reliability have provided consistent and reliable results in my research.
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