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Recombinant Human pregnancy-associated plasma protein A, pappalysin 1, His-tagged

Cat. No.: PAPPA -281H
Product Overview: Recombinant Human PAPP-A comprises a 191 amino acid fragment (81-271) corresponding to the PAPP-A 'Jelly-Roll' domain fragment and is expressed in E. coli with an aminoterminal hexahistidine tag.
Description: PAPP-A is a large zinc binding protein, which acts as a metalloprotease and has been shown to cleave insulin-like growth factor binding protein-4. PAPP-A can act as a regulator of IGF bioactivity in several biological systems, including the human ovary and cardiovascular systems. Recent studies have shown that levels are elevated in patients with unstable angina or acute myocardial infarction. PAPP-A is also produced in high concentrations during pregnancy and is released into the maternal circulation. Low levels of PAPP-A have been linked with a number of foetal chromosomal abnormalities, as well as pre-eclampsia and stillbirth.
Source: E.coli.
Purity: >95% by SDS-PAGE
Form: Liquid
Storage: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.
Gene Name: PAPPA pregnancy-associated plasma protein A, pappalysin 1 [ Homo sapiens ]
Synonyms: Pappalysin-1; Pregnancy-Associated Plasma Protein-1; Insulin-like growth factor-dependent IGF binding protein-4; EC 3.4.24.79; IGF-dependent IGFBP-4 protease; IGFBP-4ase; PAPPA; PAPA; ASBABP2; DIPLA1; IGFBP-4ase; PAPP-A; PAPPA1; pregnancy-associated plasma protein A, pappalysin 1; pregnancy-associated plasma protein A; OTTHUMP00000022806; aspecific BCL2 ARE-binding protein 2; differentially placenta 1 expressed protein; insulin-like growth factor-dependent IGF binding protein-4 protease.
Gene ID: 5069
mRNA Refseq: NM_002581
Protein Refseq: NP_002572
MIM: 176385
UniProt ID: Q13219
Chromosome Location: 9q33.2
Pathway: Diabetes pathways
Function: metal ion binding; metallopeptidase activity;metallopeptidase activity; peptidase activity; zinc ion binding

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