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Recombinant Zebrafish ARL13B

Cat.No. : ARL13B-9543Z
Product Overview : Recombinant Zebrafish ARL13B full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Zebrafish
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 oC for short term. For long term storage, store it at -20 oC~-80 oC.
Storage Buffer : PBS buffer
Gene Name : arl13b ADP-ribosylation factor-like 13b [ Danio rerio (zebrafish) ]
Official Symbol : ARL13B
Gene ID : 286784
mRNA Refseq : NM_173272
Protein Refseq : NP_775379
UniProt ID : Q8JHI3

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (14)

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Are there any animal models available to study ARL13B function? 03/01/2023

Yes, researchers have developed animal models, such as mice and zebrafish, with specific ARL13B gene mutations. These models help in studying the consequences of ARL13B dysfunction and its role in cilia-related diseases, providing valuable insights into the biology of ciliopathies.

Can ARL13B interact with other proteins? 01/15/2023

Yes, ARL13B can interact with various proteins involved in ciliary pathways. It interacts with other ciliary proteins, such as intraflagellar transport (IFT) proteins and BBSome components, to regulate protein trafficking and signaling within cilia.

Does ARL13B have any role outside of cilia? 12/27/2022

While ARL13B primarily functions within cilia, studies suggest that it may have additional roles outside of cilia. It has been shown to interact with components of the Golgi apparatus, suggesting potential involvement in intracellular vesicle trafficking and Golgi organization.

Are there any pharmacological approaches targeting ARL13B? 11/02/2022

Currently, there are no specific pharmacological agents targeting ARL13B. However, research is being conducted on compounds that modulate ciliary function and may indirectly affect ARL13B activity. These compounds hold potential for future therapeutic interventions for ciliopathy-related disorders.

Can ARL13B be used as a biomarker for ciliopathies? 04/19/2022

ARL13B has been suggested as a potential biomarker for ciliopathies. Its altered expression or cellular localization in patient samples may serve as indicators of ciliary dysfunction and contribute to the diagnosis and study of these disorders.

Can ARL13B mutations be inherited? 03/15/2022

Yes, mutations in the ARL13B gene can be inherited in an autosomal recessive manner. This means that both parents must be carriers of a mutated ARL13B allele to pass on the disorder to their offspring.

Are there any ongoing research studies on ARL13B? 02/02/2022

Yes, research on ARL13B is actively ongoing. Scientists continue to investigate its precise mechanisms of action, its interactions with other proteins, and its role in ciliopathy-related disorders. This research aims to improve our understanding of ciliogenesis and develop potential therapeutic strategies for ciliopathy treatment.

Is ARL13B conserved across species? 11/29/2021

ARL13B is conserved across various species, indicating its importance in ciliary biology. Homologs of ARL13B can be found in organisms ranging from worms to humans, suggesting its fundamental role in ciliogenesis and cilia-related processes.

Can ARL13B be targeted for potential therapeutic interventions? 05/20/2021

Targeting ARL13B directly for therapeutic purposes is challenging due to its essential role in ciliogenesis. However, research efforts are focused on finding ways to modulate downstream targets or pathways regulated by ARL13B to restore ciliary function and ameliorate ciliopathy-related symptoms.

Are there any specific human diseases associated with ARL13B mutations? 04/11/2021

Yes, mutations in the ARL13B gene have been linked to a range of ciliopathies, including Joubert syndrome, oral-facial-digital syndrome type VI (OFDVI), and Bardet-Biedl syndrome (BBS). These disorders are characterized by various clinical features, including neurological and cognitive impairments, kidney dysfunction, and skeletal abnormalities.

How does ARL13B contribute to ciliary signaling pathways? 07/11/2018

ARL13B is involved in regulating ciliary signaling pathways, such as Hedgehog signaling. It helps to localize and control the trafficking of key components involved in these pathways, ensuring the proper activation and transmission of signals within the primary cilium.

How does ARL13B regulate ciliogenesis? 05/03/2018

ARL13B plays a crucial role in the assembly and maintenance of cilia by controlling the trafficking of key components required for cilia formation. It helps in the targeting and delivery of proteins to the ciliary membrane, ensuring the proper assembly and function of this organelle.

Are there any ongoing clinical trials related to ARL13B? 06/09/2017

Currently, there are no clinical trials specifically targeting ARL13B. However, clinical trials are being conducted for various ciliopathy disorders, including those associated with ARL13B mutations. These trials explore potential treatments and interventions to manage the symptoms and complications of ciliopathies.

Is ARL13B essential for normal development? 10/25/2016

Yes, ARL13B is essential for proper embryonic development. Mutations in the ARL13B gene can cause a variety of ciliopathies, affecting multiple organ systems and leading to developmental abnormalities.

Customer Reviews (10)

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Reviews
10/02/2022

    manufacturers or suppliers of proteins can play a crucial role in supporting researchers during trials.

    06/05/2022

      Collaborating with the manufacturer opens up possibilities for potential collaboration and exchange of information with a wider scientific community, allowing researchers to stay at the forefront of advancements in their respective fields.

      08/20/2021

        The manufacturer not only ensures the provision of superior protein but also aids researchers with their solid technical support, offering the necessary resources to optimize experimental protocols.

        08/17/2020

          the manufacturer of ARL13B protein provides excellent technical support, ensuring prompt assistance and guidance.

          12/10/2019

            This includes complementary reagents, protocols, and access to an extensive knowledge base, all aimed at streamlining the trial process and maximizing the chances of achieving meaningful results.

            07/28/2019

              Its unique properties and functions make it an essential component in investigating various biological processes and molecular mechanisms.

              11/25/2018

                Their expertise and commitment to customer satisfaction make them a trusted partner in achieving research goals.

                02/15/2018

                  Their knowledgeable team is readily available to address any questions or concerns, guaranteeing a smooth experimental process.

                  12/05/2017

                    the manufacturer of ARL13B protein provides excellent technical support, ensuring prompt assistance and guidance.

                    09/22/2017

                      the ARL13B protein offers numerous advantages for researchers conducting trials due to its high quality and stability.

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