"PPP1R14A" Related Products

Recombinant Human Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A, His-tagged

Cat. No. : PPP1R14A-110H
Product Overview : Recombinant His tagged PPP1R14A was expressed in E.coli and purified by using conventional chromatography techniques (167 aa, 18 kDa).
Description : PPP1R14A (Protein phosphatase 1 regulatory subunit 14A) is a phosphorylation-dependent inhibitory protein for smooth muscle myosin phosphate. Myosin phosphatase can reverse MYL (myosin light chain) phosphorylation to induce a state of relaxation. However, during agonist-induced contraction at constant Ca2+ concurrent inhibition of myosin phosphatase leads to increases in MYL phosphorylation and tension. These calcium-independent increases in myosin phosphorylation and tension are termed calcium sensitization.
Source : E.coli.
Formulation : Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT, 2 mM EDTA, 10% glycerol.
Molecular Weight : 18 kDa (167 aa).
Purity : > 95% by SDS – PAGE.
Concentration : 1 mg/ml (determined by Bradford assay).
Sequence : MGSSHHHHHH SSGLVPRGSH MAAQRLGKRV LSKLQSPSRA RGPGGSPGGL QKRHARVTVK YDRRELQRRL DVEKWIDGRL EELYRGMEAD MPDEINIDEL LELESEEERS RKIQGLLKSC GKPVEDFIQE LLAKLQGLHR QPGLRQPSPS HDGSLSPLQD RARTAHP
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : PPP1R14A
Synonyms : PPP1R14A; protein phosphatase 1, regulatory (inhibitor) subunit 14A; CPI17; CPI-17; PPP1INL; 17 kDa PKC-potentiated inhibitory protein of PP1; PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A; 17-KDa protein; 17-kDa PKC-potentiated inhibitory protein of PP1; PKC-potentiated inhibitory protein of PP1.
Gene ID : 94274
mRNA Refseq : NM_033256.1
Protein Refseq : NP_150281.1
MIM : 608153
UniProt ID : Q96A00
Chromosome Location : 19q13.1
Function : phosphoprotein phosphatase inhibitor activity; protein binding.

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