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Recombinant Human Sirtuin 6, His-tagged

Cat.No. : SIRT6-357H
Product Overview : Recombinant Human SIRT6, fused to His-tag at N-terminus, was expressed in E.coli and purified by conventional chromatography techniques, 41 kDa (375 aa).
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Cat. No. : SIRT6-357H
Description : The SIRT6 is included in class IV of the sirtuin family, homologs to the yeast Sir2 protein. The functions of human sirtuins have not yet been determined; however, in yeast sirtuins are known to regulate epigenetic gene silencing. Also SIRT6, a chromatin-associated protein, appears to be involved in DNA repair.
Source : Escherichia Coli.
Form : Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Purity : > 95% by SDS - PAGE.
Concentration : 1 mg/ml (determined by Bradford assay)
Sequences of amino acids : MGSSHHHHHH SSGLVPRGSH MSVNYAAGLS PYADKGKCGL PEIFDPPEEL ERKVWELARL VWQSSSVVFH TGAGISTASG IPDFRGPHGV WTMEERGLAP KFDTTFESAR PTQTHMALVQ LERVGLLRFL VSQNVDGLHV RSGFPRDKLA ELHGNMFVEE CAKCKTQYVR DTVVGTMGLK ATGRLCTVAK ARGLRACRGE LRDTILDWED SLPDRDLALA DEASRNADLS ITLGTSLQIR PSGNLPLATK RRGGRLVIVN LQPTKHDRHA DLRIHGYVDE VMTRLMEHLG LEIPAWDGPR VLERALPPLP RPPTPKLEPK EESPTRINGS IPAGPKQEPC AQHNGSEPAS PKRERPTSPA PHRPPKRVKA KAVPS
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : SIRT6 sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) [ Homo sapiens ]
Synonyms : SIRT6; SIR2L6; sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae); sirtuin 6; sirtuin type 6; sir2-related protein type 6; EC 2.4.2.31; SIR2-like protein 6; sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 6.
Gene ID : 51548
mRNA Refseq : NM_016539
Protein Refseq : NP_057623
MIM : 606211
UniProt ID : Q8N6T7
Chromosome Location : 19p13.3
Function : NAD binding; NAD(P)+-protein-arginine ADP-ribosyltransferase activity; NAD+ ADP-ribosyltransferase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; metal ion binding; protein binding; transferase activity, transferring glycosyl groups; zinc ion binding.

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How is SIRT6 involved in DNA repair? 11/10/2021

SIRT6 can participate in the DNA repair process by influencing the activity of DNA repair enzymes through deacetylation modification.

What is the nutritional significance of SIRT6? 08/30/2021

This proteinexpression of genes related to fat metabolism through deacetylation modifications.

Does SIRT6 have therapeutic potential? 09/25/2020

Yes, SIRT6 has therapeutic potential. In tumor therapy, drug activation or gene therapy targeting SIRT6 may become a new avenue for treating tumors. At the same time, activators for SIRT6 are also being developed.

How does SIRT6 affect nutrient metabolism and energy balance? 05/19/2020

SIRT6 regulates the expression of specific genes through deacetylation, which in turn affects nutrient metabolism and energy balance. For example, in adipocytes, activation of SIRT6 may lead to abnormal expression of genes related to adipopocyte, which in turn affects processes such as differentiation, proliferation, and apoptosis of adipocytes.

What is the effect of loss of SIRT6 on cells? 01/31/2020

Deletion of SIRT6 may lead to cell growth arrest, increased apoptosis, and genomic instability.

How do the expression levels of SIRT6 differ in different tissues and cells? 01/01/2020

There are differences in the expression levels of SIRT6 in different tissues and cells. For example, in tissues and cells such as the reproductive system, nervous system, and immune system, there may be varying degrees of variation in the expression levels of SIRT6.

Customer Reviews (3)

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Reviews
07/21/2022

    This protein has high yield and good economic benefits.

    05/25/2022

      Laboratory staff feedback that the protein is easy to operate, can meet the needs of the experiment, and has a good cost performance.

      12/13/2021

        SIRT6 is highly expressed and can efficiently synthesize a large number of target proteins in host cells.

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