Recombinant Human Sirtuin 6, His-tagged
Cat.No. : | SIRT6-357H |
Product Overview : | Recombinant Human SIRT6, fused to His-tag at N-terminus, was expressed in E.coli and purified by conventional chromatography techniques, 41 kDa (375 aa). |
- Specification
- Gene Information
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Cat. No. : | SIRT6-357H |
Description : | The SIRT6 is included in class IV of the sirtuin family, homologs to the yeast Sir2 protein. The functions of human sirtuins have not yet been determined; however, in yeast sirtuins are known to regulate epigenetic gene silencing. Also SIRT6, a chromatin-associated protein, appears to be involved in DNA repair. |
Source : | Escherichia Coli. |
Form : | Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol |
Purity : | > 95% by SDS - PAGE. |
Concentration : | 1 mg/ml (determined by Bradford assay) |
Sequences of amino acids : | MGSSHHHHHH SSGLVPRGSH MSVNYAAGLS PYADKGKCGL PEIFDPPEEL ERKVWELARL VWQSSSVVFH TGAGISTASG IPDFRGPHGV WTMEERGLAP KFDTTFESAR PTQTHMALVQ LERVGLLRFL VSQNVDGLHV RSGFPRDKLA ELHGNMFVEE CAKCKTQYVR DTVVGTMGLK ATGRLCTVAK ARGLRACRGE LRDTILDWED SLPDRDLALA DEASRNADLS ITLGTSLQIR PSGNLPLATK RRGGRLVIVN LQPTKHDRHA DLRIHGYVDE VMTRLMEHLG LEIPAWDGPR VLERALPPLP RPPTPKLEPK EESPTRINGS IPAGPKQEPC AQHNGSEPAS PKRERPTSPA PHRPPKRVKA KAVPS |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Gene Name : | SIRT6 sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) [ Homo sapiens ] |
Synonyms : | SIRT6; SIR2L6; sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae); sirtuin 6; sirtuin type 6; sir2-related protein type 6; EC 2.4.2.31; SIR2-like protein 6; sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 6. |
Gene ID : | 51548 |
mRNA Refseq : | NM_016539 |
Protein Refseq : | NP_057623 |
MIM : | 606211 |
UniProt ID : | Q8N6T7 |
Chromosome Location : | 19p13.3 |
Function : | NAD binding; NAD(P)+-protein-arginine ADP-ribosyltransferase activity; NAD+ ADP-ribosyltransferase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; metal ion binding; protein binding; transferase activity, transferring glycosyl groups; zinc ion binding. |
Products Types
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◆ Lysates | ||
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◆ Assay kits | ||
Kit-2341 | SIRT6 Inhibitor Screening Kit (Fluorometric) | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionSIRT6 can participate in the DNA repair process by influencing the activity of DNA repair enzymes through deacetylation modification.
This proteinexpression of genes related to fat metabolism through deacetylation modifications.
Yes, SIRT6 has therapeutic potential. In tumor therapy, drug activation or gene therapy targeting SIRT6 may become a new avenue for treating tumors. At the same time, activators for SIRT6 are also being developed.
SIRT6 regulates the expression of specific genes through deacetylation, which in turn affects nutrient metabolism and energy balance. For example, in adipocytes, activation of SIRT6 may lead to abnormal expression of genes related to adipopocyte, which in turn affects processes such as differentiation, proliferation, and apoptosis of adipocytes.
Deletion of SIRT6 may lead to cell growth arrest, increased apoptosis, and genomic instability.
There are differences in the expression levels of SIRT6 in different tissues and cells. For example, in tissues and cells such as the reproductive system, nervous system, and immune system, there may be varying degrees of variation in the expression levels of SIRT6.
Customer Reviews (3)
Write a reviewThis protein has high yield and good economic benefits.
Laboratory staff feedback that the protein is easy to operate, can meet the needs of the experiment, and has a good cost performance.
SIRT6 is highly expressed and can efficiently synthesize a large number of target proteins in host cells.
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