Cat. No. : | SNCA-291H |
Product Overview : | Recombinant Human α-SynucleinDelta-NAC protein produced in E.Coli encodes 111 amino acids and has a molecular mass of 11.9 kDa. |
Description : | A deletion mutant of α-synuclein that lacks the NAC region (amino acid 61-95). α-synuclein(ΔNAC) was overexpressed in E. coli and purified to apparent homogeneity by taking advantage of the thermosolubility of the protein and by using conventional column chromatography techniques. 6 amino acids were added as a linker. |
Source : | E.coli. |
Formulation : | Liquid. In 20 mM Tris-HCl buffer (pH 7.5) containing 0.1 M NaCl. |
Molecular Weight : | 11.9 kDa (111 aa) (Real molecular size on SDS-PAGE will be shift up). |
Purity : | >95% by SDS PAGE. |
Concentration : | 1mg/ml (determined by BCA assay). |
Sequence : | MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK GTEIWMKKDQ LGKNEEGAPQ EGILEDMPVD PDNEAYEMPS EEGYQDYEPE A |
Storage : | Store at -20 °C. Avoid freeze/thaw cycles. |
Gene Name : | SNCA |
Synonyms : | SNCA; synuclein, alpha (non A4 component of amyloid precursor); PD1; NACP; PARK1; PARK4; MGC110988; alpha-synuclein, isoform NACP140; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; alpha-synuclein; OTTHUMP00000161559; OTTHUMP00000161561; non A-beta component of AD amyloid; synuclein, alpha (non A4 component of amyloid precursor); Synuclein, alpha (non-Abeta component of Alzheimer"s disease amyloid precursor protein: NACP). |
Gene ID : | 6622 |
mRNA Refseq : | NM_000345.3 |
Protein Refseq : | NP_000336.1 |
MIM : | 163890 |
UniProt ID : | P37840 |
Chromosome Location : | 4q21 |
Pathway : | Alzheimer"s disease; Neurodegenerative Disorders;Parkinson"s disease. |
Function : | Hsp70 protein binding; alpha-tubulin binding;dynein binding; histone binding; kinesin binding; tau protein binding; transferrin transmembrane transporter activity. |
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