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Active Recombinant Human PAK6

Cat.No. : PAK6-19H
Product Overview : PAK6KD is a recombinant wild type human PAK6 kinase domain (amino acids 385–680 of full-length human PAK6) expressed in E. coli and purified to homogeneity with full activity.
  • Specification
  • Gene Information
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Description : Human PAK6 kinase (UniProt: Q9NQU5; NCBI: NM_020168) belongs to a family of p21-activated kinases. These serine/threonine kinases are regulated by the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK6 was found to interact with androgen receptor.
Source : E. coli
Species : Human
Form : 1 mg/ml in Storage Buffer of 25 mM Tris-HCl pH 8.0, 150 mM NaCl, 10% glycerol, 5 mM DTT.
Bio-activity : 2,086 pmoles/min/μg
Molecular Mass : The calculated mass is 34,161. PAK6KD is fully phosphorylated at S560 with a measured mass of 34,242 (1P).
AA Sequence : GPHPVTHEQFKAALRMVVDQGDPRL LLDSYVKIGEGSTGIVCLAREKHSG RQVAVKMMDLRKQQRRELLFNEVVI MRDYQHFNVVEMYKSYLVGEELWVL MEFLQGGALTDIVSQVRLNEEQIAT VCEAVLQALAYLHAQGVIHRDIKS DSILLTLDGRVKLSDFGFCAQISKD VPKRKSLVGTPYWMAPEVISRSLYA TEVDIWSLGIMVIEMVDGEPPYFS DSPVQAMKRLRDSPPPKLKNSHKVS PVLRDFLERMLVRDPQERATAQELL DHPFLLQTGLPECLVPLIQLYRKQ TST
Applications : Enzymatic studies, inhibitor screen, and selectivity profiling
Storage : Stable at -70oC for 12 months from date of receipt. Protein should be thawed on ice. Protein can be flash-frozen in liquid nitrogen and stored at -70oC.
Gene Name : PAK6 p21 protein (Cdc42/Rac)-activated kinase 6 [ Homo sapiens ]
Official Symbol : PAK6
Synonyms : PAK6; p21 protein (Cdc42/Rac)-activated kinase 6; p21(CDKN1A) activated kinase 6; serine/threonine-protein kinase PAK 6; PAK5; PAK-5; PAK-6; p21-activated kinase 6; p21(CDKN1A)-activated kinase 6; p21-activated protein kinase 6;
Gene ID : 56924
mRNA Refseq : NM_001128628
Protein Refseq : NP_001122100
MIM : 608110
UniProt ID : Q9NQU5
Chromosome Location : 15q14
Pathway : Activation of Rac, organism-specific biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; ErbB signaling pathway, organism-specific biosystem;
Function : ATP binding; nucleotide binding; protein serine/threonine kinase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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