Recombinant Human Prorenin, His-tagged
Cat.No. : | REN -16H |
Product Overview : | Recombinantly produced in HEK cell culture and purified by chelated metal affinity chromatography. Contains a 8X-Histidine tag at C terminus for purification. Fully activatable to renin by catalytic amounts of trypsin. |
- Specification
- Gene Information
- Related Products
Description : | Prorenin is a glycosylated aspartic protease that consists of 2 homologous lobes and is the precursor of renin. Prorenin exhibits a low level of enzymatic activity relative to renin which is generated from prorenin by proteolytic cleavage of the first ~43 amino acids at the N-terminus. This so called prosegment appears to block the full enzymatic potential of the active site . Renin activates the renin-angiotensin system by cleaving angiotensinogen, produced by the liver, to yield angiotensin I, which is further converted into angiotensin II by ACE, the angiotensin-converting enzyme primarily within the capillaries of the lungs. It has been reported that the levels of circulating prorenin (but not renin) are increased in diabetic subjects. |
Source : | Human Embryonic Kidney cells |
Species : | Human |
Tag : | 8x His tag |
Form : | Frozen liquid |
Molecular Mass : | 43,725 |
Purity : | >95% by SDS-PAGE analysis |
Usage : | For in vitro laboratory use only |
Notes : | Optimal experimental conditions and working dilutions must be determined by the end user. Sample concentration and volume are for example purposes only and do not necessarily represent the product that will be received. Please contact us for a current lot-specific product datasheet. |
Storage : | -70°C |
Concentration : | 1.0 mg/ml |
Storage Buffer : | 50mM Tris; pH 8.0 |
Shipping : | Dry ice |
Gene Name : | REN renin [ Homo sapiens ] |
Official Symbol : | REN |
Synonyms : | REN; renin; angiotensinogenase; renin precursor, renal; angiotensin-forming enzyme; HNFJ2; FLJ10761; |
Gene ID : | 5972 |
mRNA Refseq : | NM_000537 |
Protein Refseq : | NP_000528 |
MIM : | 179820 |
UniProt ID : | P00797 |
Chromosome Location : | 1q32 |
Pathway : | ACE Inhibitor Pathway, organism-specific biosystem; Renin-angiotensin system, organism-specific biosystem; Renin-angiotensin system, conserved biosystem; |
Function : | aspartic-type endopeptidase activity; insulin-like growth factor receptor binding; peptidase activity; receptor binding; |
Products Types
◆ Recombinant Protein | ||
REN-1208H | Recombinant Human REN Protein, His-tagged | +Inquiry |
REN-1207D | Recombinant Dog REN Protein, His-tagged | +Inquiry |
REN-56H | Recombinant Human REN Protein | +Inquiry |
REN-5472D | Recombinant Dog Renin, His-tagged | +Inquiry |
REN-11H | Recombinant Human REN Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
Ren -72R | Recombinant Rat Prorenin, His tag | +Inquiry |
REN-245H | Active Native Human Renin | +Inquiry |
REN-388H | Active Native Human Renin Antigen | +Inquiry |
◆ Lysates | ||
REN-2862HCL | Recombinant Human REN cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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