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Non-cleavable Recombinant Human Tpa

Cat.No. : PLAT -79H
Product Overview : The addition of an arginine to glutamic acid mutation generates human tPA that is 100percent single chain and resistant to cleavage by plasmin. The mutation site is R275E on the mature protein and R310E on the complete mRNA sequence (UniProtKB: locus TPA_HUMAN, accession P00750). Recombinantly produced in insect cells.
  • Specification
  • Gene Information
  • Related Products
Source : Insect cell
Species : Human
Form : Frozen liquid
Molecular Mass : 70,000
Purity : >95% by SDS-PAGE analysis
Usage : For in vitro laboratory use only
Notes : Optimal experimental conditions and working dilutions must be determined by the end user. Sample concentration and volume are for example purposes only and do not necessarily represent the product that will be received. Please contact us for a current lot-specific product datasheet.
Storage : -70°C
Concentration : 2.0 mg/ml
Storage Buffer : 0.4M HEPES; 0.1M NaCl; pH 7.4
Shipping : Dry ice
Gene Name : PLAT plasminogen activator, tissue [ Homo sapiens ]
Official Symbol : PLAT
Synonyms : PLAT; plasminogen activator, tissue; tissue-type plasminogen activator; alteplase; reteplase; t-plasminogen activator; plasminogen activator, tissue type; tissue plasminogen activator (t-PA); TPA; T-PA; DKFZp686I03148;
Gene ID : 5327
mRNA Refseq : NM_000930
Protein Refseq : NP_000921
MIM : 173370
UniProt ID : P00750
Chromosome Location : 8p11.21
Pathway : Blood Clotting Cascade, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Dissolution of Fibrin Clot, organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; Hemostasis, organism-specific biosystem;
Function : peptidase activity; protein binding; serine-type endopeptidase activity; serine-type endopeptidase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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