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Active Recombinant Human Superoxide Dismutase

Cat.No. : SOD1-8H
Product Overview : Human SOD is produced in genetically engineered yeast, and purified by ionic exchange chromatography.
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  • Gene Information
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Description : Cu/Zn Human Superoxide Dismutase is a stable dimer of identical subunits with a combined molecular mass of 32,000 daltons. This enzyme dismutes the superoxide radical to molecular oxygen. This enzyme has been expressed in yeast and purified using sequential chromatography steps. The hSOD is acetylated at its N-terminus.
Source : yeast
Species : Human
Form : 10 mg/ml in water (no additive is added)
Bio-activity : The specific activity of SOD is 260 U/mg. The enzymatic activity of human SOD is determined by calorimetrically determining the oxidation of a chromophore. This was performed with a commercially available kit called SOD-525 from Bioxytech S.A. (Cedex, France).
Molecular Mass : 32 KDa (dimeric protein)
Purity : Over 98% pure by non-reduced SDS gel electrophoresis.
Stability : Several months at -20°C.
Storage : Store at -20°C.
Gene Name : SOD1?superoxide dismutase 1, soluble [?Homo sapiens?(human) ]
Official Symbol : SOD1
Synonyms : SOD1; S; SOD; ALS1; IPOA; hSod1; homodimer; superoxide dismutase [Cu-Zn]; SOD, soluble; OTTHUMP00000107278; OTTHUMP00000107279; indophenoloxidase A; Cu/Zn superoxide dismutase; superoxide dismutase, cystolic
Gene ID : 6647
mRNA Refseq : NM_000454
Protein Refseq : NP_000445
MIM : 147450
UniProt ID : P00441
Chromosome Location : 21q22.11
Pathway : Amyotrophic lateral sclerosis (ALS); FOXA1 transcription factor network; Folate Metabolism; Formation of Platelet plug; Hemostasis; Huntington"s disease; Oxidative Stress;
Function : chaperone binding; copper ion binding; copper ion binding; oxidoreductase activity; protein binding; protein homodimerization activity; protein phosphatase 2B binding; superoxide dismutase activity; zinc ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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Are there potential therapeutic strategies targeting SOD1 for disease treatment? 01/23/2022

Therapeutic strategies may involve modulating SOD1 activity or expression to mitigate oxidative stress-related damage.

What is the primary biological function of SOD1 in cells? 01/03/2022

SOD1 acts as an antioxidant, converting superoxide radicals to hydrogen peroxide and oxygen.

What are the genetic implications of mutations in the SOD1 gene? 03/01/2021

Mutations in SOD1 can result in loss or gain of function, contributing to disease development.

How is SOD1 implicated in neurodegenerative diseases? 02/09/2020

SOD1 mutations are implicated in Amyotrophic Lateral Sclerosis (ALS), leading to neurodegeneration.

In which cellular compartments is SOD1 primarily located? 11/14/2019

SOD1 is primarily located in the cytoplasm and mitochondrial intermembrane space.

What role does SOD1 play in maintaining cellular redox balance? 08/27/2019

It helps maintain cellular redox balance, protecting cells from oxidative damage.

How does SOD1 contribute to the cellular antioxidant defense system? 02/27/2019

It plays a crucial role in cellular defense against oxidative stress.

Customer Reviews (3)

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Reviews
11/15/2022

    Worked perfectly, no problems.

    10/09/2020

      Quick delivery, fantastic product.

      10/02/2020

        Reliable results every time.

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