Active Recombinant Human CCL4

• Cat.No.: CCL4-16H
• Product Overview: Human recombinant MIP-1 beta is produced in genetically engineered yeast, and purified by sequential chromatography.

Specification

• Description: Macrophage Inflammatory Protein MIP-1 beta is part of the CC subfamily of the chemokine superfamily of chemoattractant cytokines. MIP-1 beta affects the inflammatory response of blood monocytes, tissue macrophages, and T cells. MIP-1 beta also enhances the formation of granulocyte-macrophage colonies stimulated by GM-CSF or M-CSF. Human MIP-1 beta is composed of 69 amino acid residues with one possible N-linked glycosylation sites, and several possible O-linked sites. Human MIP-1 beta is 60% homologous with human MIP-1 beta.
• Source: yeast
• Species: Human
• Form: In water at a concentration of 1.0 mg protein/ml
• Bio-activity: The biological activity of recombinant human MIP-1 alpha is determined by its use as a cofactor for CSF-dependent myelopoiesis.
• Molecular Mass: 8 KDa
• Purity: Over 95% pure by SDS gel electrophoresis, with low level of endotoxin.
• Stability: Several months at -80°C.
• Storage: Store at -80°C.

Gene Information

• Gene Name: CCL4 chemokine (C-C motif) ligand 4 [ Homo sapiens (human) ]
• Official Symbol: CCL4
• Synonyms: ACT2; G-26; LAG1; MIP1B; SCYA2; SCYA4; MIP1B1; AT744.1; MIP-1-beta; CCL4; chemokine C-C motif ligand 4; CC chemokine ligand 4; secreted protein G-26; lymphocyte-activation gene 1; small inducible cytokine A4 (homologous to mouse Mip-1b); Macrophage inflammatory protein 1-beta; Short name=MIP-1-beta; MIP-1-beta(1-69); T-cell activation protein 2; Short name=ACT-2; PAT 744; Protein H400; SIS-gamma; Lymphocyte activation gene 1 protein; Short name=LAG-1; HC21; T-lymphocyte-secreted protein; MIP-1-beta(3-69); LAG1; MGC104418; MGC126025; MGC126026
• Gene ID: 6351
• mRNA Refseq: NM_002984
• Protein Refseq: NP_002975
• MIM: 182284
• UniProt ID: P13236
• Chromosome Location: 17q12
• Pathway: Chemokine signaling pathway; Cytokine-cytokine receptor interaction; Toll-like receptor signaling pathway
• Function: chemokine activity; receptor signaling protein; tyrosine kinase activity