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Native Human Kininogen, LMW

Cat.No.: KNG1-18H
Product Overview: Native Human Kininogen(LMW) was purified from Human Plasma
Description: This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.
Source: Human Plasma
Species: Human
Form: Lyophilized from 10 mM Na acetate, pH 5.5, with 200 mM NaCl.
Molecular Mass: 65000
Purity: >=95% by SDS-PAGE
Stability: > 1year
Storage: <= -20o C
Gene Name: KNG1 kininogen 1 [ Homo sapiens (human) ]
Official Symbol: KNG1
Synonyms: KNG1; kininogen 1; BDK; KNG;kininogen-1; HMWK; bradykinin; fitzgerald factor; OTTHUMP00000197128;OTTHUMP00000197129; OTTHUMP00000210109; high molecular weight kininogen;alpha-2-thiol proteinase inhibitor; williams-Fitzgerald-Flaujeac factor;Alpha-2-thiol proteinase inhibitor; Fitzgerald factor; High molecular weightkininogen; Williams-Fitzgerald-Flaujeac factor
Gene ID: 3827
mRNA Refseq: NM_000893
Protein Refseq: NP_000884
MIM: 612358
UniProt ID: P01042
Chromosome Location: 3q27
Pathway: ACEInhibitor Pathway; Class A/1 (Rhodopsin-like receptors); Complement andCoagulation Cascades; Formation of Fibrin Clot (Clotting Cascade); G alpha(i) signalling events; GPCR downstream signaling; GPCR ligand binding;
Function: cysteine-typeendopeptidase inhibitor activity; heparin binding; peptidase inhibitoractivity; receptor binding; zinc ion binding

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