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Recombinant Human SMARCA4, His-tagged

Cat.No.: SMARCA4-1915H
Product Overview: Recombinant Human SMARCA4(a.a. 1480-1603), fused with N-terminal His-tag, was expressed in an E. coli expression system.
Description: The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene.
Source: E. coli
Species: Human
Tag: His
Form: 50 mM Tris-HCl, pH 8.0, 138 mM NaCl, 2.7 mM KCl, 0.05% Tween-20, and 10% glycerol
Molecular Mass: 15.5 kDa
Protein length: 1480-1603
Purity: ≥95%
Applications: Useful for the study of bromodomain binding assays, screening inhibitors, and selectivity profiling.
Storage: >6 months at –80°C. Avoid freeze/thaw cycles.
Concentration: 2.34 mg/ml
Gene Name: SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 [ Homo sapiens (human) ]
Official Symbol: SMARCA4
Synonyms: SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; SNF2L4; transcription activator BRG1; ATP dependent helicase SMARCA4; BAF190; brahma protein like 1; BRG1; BRM/SWI2 related gene 1; FLJ39786; global transcription activator homologous sequence; homeotic gene regulator; hSNF2b; mitotic growth and transcription activator; nuclear protein GRB1; SNF2; SNF2 BETA; SNF2 like 4; SNF2LB; sucrose nonfermenting like 4; SWI2; BAF190A; SNF2-like 4; protein BRG-1; brahma protein-like 1; BRM/SWI2-related gene 1; protein brahma homolog 1; BRG1-associated factor 190A; sucrose nonfermenting-like 4; ATP-dependent helicase SMARCA4; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; RTPS2; SNF2-BETA
Gene ID: 6597
mRNA Refseq: NM_001128849
Protein Refseq: NP_001122321
MIM: 603254
UniProt ID: P51532
Chromosome Location: 19p13.2
Pathway: Chromatin modifying enzymes; Chromatin organization; Integrated Breast Cancer Pathway; RMTs methylate histone arginines
Function: ATP binding; DNA-dependent ATPase activity; contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding

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